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Novel analgesics from plant- and animal associated microorganisms

Award Number: R21AT013576
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/21/2026
PERIOD OF PERFORMANCE END DATE: 06/30/2028

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Novel analgesics from plant- and animal associated microorganisms - PROJECT ABSTRACT Pain is a leading cause of disability and there is an urgent need to develop improved therapeutic approaches for affected individuals. Natural products, or compounds isolated from biological organisms, account for a large fraction of clinically approved drugs. The small molecules produced by bacteria and fungi associated with plants and animals are an especially promising source for new drug leads, since they have exceptional chemical diversity and include a broad range of neuroactive compounds. However, challenges associated with current drug discovery strategies have limited prior efforts to identify novel natural products with pain-relieving or analgesic activity. This project overcomes these obstacles using a strategy that leverages newly developed in vivo assays and advanced imaging methods. A zebrafish-based model for nociceptive pain was established and used to identify plant- and animal- associated microbial metabolites with analgesic activity. Aim 1 of this project will identify the active principle from microbial extracts. Aim 2 will identify the mechanism of action of previously isolated lead compounds using a combination of in vitro assays with mammalian cells, and in vivo recordings of neural activity using zebrafish. This project is led by a multi-disciplinary team with expertise in both natural products drug discovery and systems neuroscience. It will identify and characterize natural products with in vivo analgesic activity, which are critically needed as drug leads and molecular probes for developing improved treatment options for pain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $422,125 )
2026	2026	UNIVERSITY OF FLORIDA	1523 UNION RD RM 207	GAINESVILLE	FL	32611	ALACHUA	USA	Research and Training in Complementary and Integrative Health	000	1	7/23/2026	NEW	$422,125
														Subtotal = $422,125

Grand Total All Awards = $422,125

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Novel analgesics from plant- and animal associated microorganisms

Award Number: R21AT013576

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/21/2026

PERIOD OF PERFORMANCE END DATE: 06/30/2028

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