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Regulation of Sarcomere Growth

Award Number: R21AR085415
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Regulation of Sarcomere Growth - PROJECT SUMMARY/ABSTRACT It is well established that the addition or removal of sarcomeres is central in determining muscle size and force output during normal development, but also in response to mechanical stimuli or pathological conditions. Overstretched muscle can initiate new sarcomere formation, while chronic understretching reduces sarcomere number and may shorten muscle lengths. Other than disease states or mechanical-load induced alterations, few studies have examined force-independent factors that influence skeletal muscle sarcomere remodeling. Moreover, a major knowledge gap is understanding how muscle-intrinsic factors contribute to sarcomere addition during muscle growth. To address these deficiencies, we have established genetic backgrounds that promote larval muscle growth to quantitatively study serial sarcomere addition at a single-cell resolution in the experimentally tractable Drosophila model. Completion of the following two aims will help us accomplish our long-term goal of understanding how muscle length increases at both the sarcomere and whole tissue levels during development and growth. Aim 1 will determine the identity of molecular targets that impact sarcomere addition using transcriptomic and candidate approaches. Aim 2 will use in vivo protein tagging methods to follow the fate of newly synthesized sarcomere proteins during muscle growth. We expect that this project will fundamentally advance our understanding of signaling pathways required for sarcomere addition and will establish new techniques for studying sarcomere dynamics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $352,777 )
2025	2025	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/7/2025	NEW	$352,777
														Subtotal = $352,777

Grand Total All Awards = $352,777

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Regulation of Sarcomere Growth

Award Number: R21AR085415

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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