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Pathologic consequences of epidermal lipase deficiencies

Award Number: R21AR084158
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/20/2024
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Pathologic consequences of epidermal lipase deficiencies - PROJECT SUMMARY/ABSTRACT The biological function of skin enriched lipases (epidermal lipases) K, M and N are not defined. Some people with autosomal recessive congenital ichthyosis harbor disease associated Lipase N mutations, suggesting a clinically relevant role for this protein in skin health. In addition, our recent work indicates lipase M is critical for skin development and function and that epidermal lipase transcripts are reduced in a chronic lesion of atopic dermatitis. These observations suggest epidermal lipases M, N, and, potentially, K, are important for skin development and that defects or deficiencies of one or more of these proteins may contribute to some types of ichthyoses and atopic dermatitis. In light of these observations, the primary goal of this research is to use novel experimental systems to understand the biological consequences of epidermal lipases K, M and N deficiency in skin development and function. The proposed studies will use human skin equivalents lacking expression of individual epidermal lipases (Aim 1) and an inducible lipase M conditional knock out mouse model (Aim 2) to understand the pathologic consequences of epidermal lipase deficiencies. Understanding the consequences of epidermal lipase deficiencies may provide insights into the molecular functions of these proteins and could lead to novel therapies for inherited ichthyoses and atopic dermatitis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $169,120 )
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	5/26/2025	NON-COMPETING CONTINUATION	$12,205
2025	2025	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	1/22/2025	NON-COMPETING CONTINUATION	$156,915
														Subtotal = $169,120

Issue Date FY: 2024 ( Subtotal = $209,220 )
2024	2024	TRUSTEES OF INDIANA UNIVERSITY	980 INDIANA AVE RM 2232	INDIANAPOLIS	IN	46202	MARION	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	2/19/2024	NEW	$209,220
														Subtotal = $209,220

Grand Total All Awards = $378,340

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Pathologic consequences of epidermal lipase deficiencies

Award Number: R21AR084158

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/20/2024

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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