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Development of a Synovium-on-a-Chip Microphysiological System to Interrogate Pathobiology and Enhance Precision Medicine in Rheumatoid Arthritis

Award Number: R21AR083247
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Development of a Synovium-on-a-Chip Microphysiological System to Interrogate Pathobiology and Enhance Precision Medicine in Rheumatoid Arthritis - PROJECT SUMMARY Rheumatoid arthritis (RA) is the most common inflammatory joint disease caused by a chronic inflammation in joints, where no effective treatment is currently available. Currently there is no effective model can accurately dissect RA pathogenesis and consistently predict the effect of a therapeutic agent in patients. Better model systems that can accurately recapitulate the immune responses and pathological processes of RA in the human synovial microenvironment with immunomodulatory treatments are critically required. In this work we aim to develop a fully patient-derived in vitro RA disease model termed “Synovium-on-a-Chip” by including full spectrum of synovial cell types, which can serve as a precision medicine platform to (1) interrogate human RA pathobiology and to (2) achieve clinical trial on chips for stratifying patients and pre-screening of novel immunotherapy. Simulating the structure and inflammatory microenvironment of the synovium with such a biomimetic vascularized immunocompetent microphysiological system will represent a major advance over existing models, providing much greater biomimicry and enabling next-step studies to allow rational selection of immunomodulatory drugs to personalize treatment of RA patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $179,469 )
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	5/20/2025	NON-COMPETING CONTINUATION	$12,951
2025	2025	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	3/10/2025	NON-COMPETING CONTINUATION	$166,518
														Subtotal = $179,469

Issue Date FY: 2024 ( Subtotal = $235,690 )
2024	2024	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	2/26/2024	NEW	$235,690
														Subtotal = $235,690

Grand Total All Awards = $415,159

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Development of a Synovium-on-a-Chip Microphysiological System to Interrogate Pathobiology and Enhance Precision Medicine in Rheumatoid Arthritis

Award Number: R21AR083247

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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