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In-vivo polymicrobial biofilms resulting in implant corrosion and metallosis

Award Number: R21AR080873
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/19/2022
PERIOD OF PERFORMANCE END DATE: 11/30/2024

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In-vivo polymicrobial biofilms resulting in implant corrosion and metallosis - ABSTRACT Metallosis is a term used to describe staining of tissues exposed to metal particles and ions in- vivo. There is no explicit diagnosis for metallosis, but it is recognized as a significant health threat per the FDA as the released metals are associated with cardiotoxicity, neurotoxicity, and cancers. The overarching hypothesis of this work is that in-vivo non-pathogenic bacterial biofilms on spinal hardware affect the release of metal via corrosion thus causing metallosis in patients. To test this hypothesis, we will pursue the following aims: Specific Aim 1 will examine the association of bacteria with observed corrosion on the surfaces of spine hardware via the quantification of surface damage and the presence of bacterial associated biomolecules integrated into the damaged surfaces. To do so we will use surface optical microscopy to quantify the type and area coverage of surface modification whether wear or corrosion, over the entire device component, pedicel screw or rod. Optical microscopy determination of corrosion regions without existing mechanical damage will elucidate the total possible amount of metal release based on surface area measurements. How these surfaces are modified beyond mechanical damage will be characterized using Time of Flight-Scanning Ion Mass Spectroscopy (TOF-SIMS) and X-ray Photoelectron Spectroscopy (XPS). Work in Specific Aim 2 will characterize the bacterial milieu constituting the biofilms on explanted spine hardware in metallosis cases. Because of the lack of understanding of the in-vivo spinal instrumentation microbiome, this Aim will identify the common microbes associated with implant corrosion. The impact of this work will be to give insight to the mechanisms of in-vivo metal corrosion, thus leading to possible changes in clinical treatments, the necessity of new or modified materials, or changes to surgical procedures to reduce the risk of metallosis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $165,919 )
2024	2024	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	12/1/2023	NON-COMPETING CONTINUATION	$153,945
2024	2024	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	6/13/2024	NON-COMPETING CONTINUATION	$11,974
														Subtotal = $165,919

Issue Date FY: 2023 ( Subtotal = $205,260 )
2023	2023	REGENTS OF THE UNIVERSITY OF COLORADO, THE	13001 E 17TH PLACE F428	AURORA	CO	80045	ADAMS	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	12/19/2022	NEW	$205,260
														Subtotal = $205,260

Grand Total All Awards = $371,179

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In-vivo polymicrobial biofilms resulting in implant corrosion and metallosis

Award Number: R21AR080873

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/19/2022

PERIOD OF PERFORMANCE END DATE: 11/30/2024

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