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Extracellular RNA Expression Biomarkers in Osteoarthritis Disease and Progression

Award Number: R21AR080270
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Osteoarthritis (OA) is a progressive and degenerative joint disease with an increasing prevalence in the aging population for which existing treatments targeting the primary symptom of pain are only minimally successful. The manifestation of OA is heterogeneous with symptomology differing across individuals. This disease heterogeneity has made identification of reliable and consistent molecular biomarkers elusive. This has in part hindered the progress toward development of specific therapeutic treatments. Therefore, the identification of specific biomarkers of OA clinical phenotypes and longitudinal changes over disease progression is required. To begin addressing this issue, here we propose an initiative for the discovery of plasma extracellular RNA (exRNA) expression signatures genomic signatures of OA among diverse clinical and progressive phenotypes. exRNA has been demonstrated in a variety of complex diseases to have prognostic and biological value. The experiments will utilize the Osteoarthritis Initiative (OAI) which is a prospective, longitudinal multicenter cohort study of nearly 5000 subjects diagnosed with radiographic knee OA or at risk for the disease. We will first cluster the entire OAI cohort into distinct clinical phenotypes based on biochemical assays, imaging data, and clinical symptom questionnaires and identify exRNA signatures associated with those phenotypes using high throughput RNA sequencing (SA1). Furthermore, we will identify individuals with progressive OA defined as progression by radiograph changes over time as well as increasing pain over time. We will then generate longitudinal time- course profiles of exRNA expression to deduce biological mechanisms of that progression (SA2). By generating specific phenotype definitions, this study has increased power to identify molecular signatures of these OA groups. This will be an important step toward harnessing the value of functional genomics as a biomarker in the precision medicine of OA.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $151,965 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	2/6/2024	NON-COMPETING CONTINUATION	$151,965
														Subtotal = $151,965

Issue Date FY: 2023 ( Subtotal = $200,501 )
2023	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	2/22/2023	NEW	$200,501
														Subtotal = $200,501

Grand Total All Awards = $352,466

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Extracellular RNA Expression Biomarkers in Osteoarthritis Disease and Progression

Award Number: R21AR080270

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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