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The Anti-Cyclic Citrullinated Protein Antibody Repertoire and Lung Involvement in Rheumatoid Arthritis

Award Number: R21AR076553
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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The Anti-Cyclic Citrullinated Protein Antibody Repertoire and Lung Involvement in Rheumatoid Arthritis - PROJECT SUMMARY/ABSTRACT Though pulmonary fibrosis (PF) is a common and morbid complication of rheumatoid arthritis (RA), little is known about who with RA is at risk for its development and what predicts progressive and lethal PF. Anti-cy- clic citrullinated protein antibodies (ACPA) are present in patients before the development of joint disease in RA and are also found in a subset of patients with usual interstitial pneumonia (UIP), the most common form of PF seen in RA and the one that carries a dismal prognosis. Mounting evidence suggests that the lungs play a key role in the formation of these ACPA and may be intimately involved in the pathogenesis of disease in a subset of patients with RA. The hypothesis of this project is that as patients evolve from pre-RA (i.e., serum or sputum autoimmunity without disease) to RA joint disease to progressive RA-UIP, there is an expansion of cit- rullinated protein targets that encompass both lung and joint specific proteins, and this repertoire can predict clinical phenotype. We will test our hypothesis by identifying 4 subgroups of patients: (1) Pre-RA, (2) UIP pre- RA, (3) RA no UIP and (4) RA-UIP. We will look at the differences in this ACPA repertoire between these co- horts, identify lung-specific ACPA targets that can predict the onset of UIP in RA and explore the relationship between these ACPA targets and progressive lung disease. This proposal helps further the mission of the Na- tional Institute of Arthritis and Musculoskeletal and Skin Diseases by proposing patient-relevant clinical re- search that tests a hypothesis on the etiology of a major co-morbidity of rheumatoid arthritis. This proposal will broaden our understanding of the relationship between RA and the lungs, uncover valuable clinically relevant biomarkers and provide caregivers with tools to predict disease onset and behavior in order to personalize treatment decisions. Long-term goals of this proposal include reducing the burden of disease, strengthening our ability to enrich cohorts for upcoming clinical trials and highlighting plausible disease pathways for future research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$2,117 )
2025	2021	NATIONAL JEWISH HEALTH	1400 JACKSON ST	DENVER	CO	80206	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	4/3/2025	NON-COMPETING CONTINUATION	-$2,117
														Subtotal = -$2,117

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	NATIONAL JEWISH HEALTH	1400 JACKSON ST	DENVER	CO	80206	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	11/8/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $174,645 )
2021	2021	NATIONAL JEWISH HEALTH	1400 JACKSON ST	DENVER	CO	80206	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	8/11/2021	NON-COMPETING CONTINUATION	$174,645
2021	2020	NATIONAL JEWISH HEALTH	1400 JACKSON ST	DENVER	CO	80206	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	1/8/2021	NEW	$0
														Subtotal = $174,645

Issue Date FY: 2020 ( Subtotal = $179,976 )
2020	2020	NATIONAL JEWISH HEALTH	1400 JACKSON ST	DENVER	CO	80206	DENVER	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/3/2020	NEW	$179,976
														Subtotal = $179,976

Grand Total All Awards = $352,504

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The Anti-Cyclic Citrullinated Protein Antibody Repertoire and Lung Involvement in Rheumatoid Arthritis

Award Number: R21AR076553

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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