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Enhancing Osseointegration of PEEK with Straight Forward Chemical Derivation Strategy

Award Number: R21AR076525
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Abstract: The on growth of bone to in hard tissue implants is a critical factor in the positive health outcomes of these medical procedures. In order for a material to enable bone on growth the implant material’s interface with the body must have a surface conducive for cellular attachment and growth. Therefore methods to improve an implant materials ability to foster cell growth and adhesion are critical for the creation of next generation surgical implant devices and enhanced medical outcomes. Poly(ether ether ketone) (PEEK) is a important biocompatible polymer implant used in a range of hard tissue applications including spine, long bone, skull flap, and orthopedic applications. PEEK’s major limitation relates to its inert surface and lack of surface charge leading to poor cellular attachment and the potential for implant failure. In this proposal we study how a facile aqueous based surface modification of PEEK impacts that materials ability to promote cell growth in vitro and promote bone on growth in vivo.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	ALLEGHENY SINGER RESEARCH INSTITUTE	320 E NORTH AVE	PITTSBURGH	PA	15212	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	11/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	ALLEGHENY-SINGER RESEARCH INSTITUTE	320 E NORTH AVE	PITTSBURGH	PA	15212	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	5/25/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $201,543 )
2021	2021	ALLEGHENY-SINGER RESEARCH INSTITUTE	320 E NORTH AVE	PITTSBURGH	PA	15212	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	7/16/2021	NON-COMPETING CONTINUATION	$201,543
														Subtotal = $201,543

Issue Date FY: 2020 ( Subtotal = $185,791 )
2020	2020	ALLEGHENY-SINGER RESEARCH INSTITUTE	320 E NORTH AVE	PITTSBURGH	PA	15212	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	7/21/2020	NEW	$15
2020	2020	ALLEGHENY-SINGER RESEARCH INSTITUTE	320 E NORTH AVE	PITTSBURGH	PA	15212	ALLEGHENY	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/17/2020	NEW	$185,776
														Subtotal = $185,791

Grand Total All Awards = $387,334

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Enhancing Osseointegration of PEEK with Straight Forward Chemical Derivation Strategy

Award Number: R21AR076525

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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