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Efficacy of a whole inactivated vaccine against EV-D68 infection

Award Number: R21AI199351
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/22/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2028

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Efficacy of a whole inactivated vaccine against EV-D68 infection - ABSTRACT Enterovirus D68 (EV-D68) is a remerging virus that causes polio like illness in children. Numerous outbreaks of EV-D68 infections have been reported worldwide since 2014 that is expected to increase in both the frequency and magnitude in the coming years raising the prospect of a rise in polio like paralytic cases in children. There are currently no approved vaccines against EV-D68. Here we propose to develop a whole inactivated vaccine using a novel approach capable of preserving conformational neutralizing antibody epitopes leading to protection from acute respiratory and spinal pathology. In aim 1, we will determine if a whole inactivated EV-D68 vaccine will prevent acute respiratory pathology, and in aim 2, we will examine in vaccination will prevent AFM like disease. Overall these studies will provide insights that will aid in the development of a highly efficacious vaccine against EV-D68 infection.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $223,728 )
2026	2026	THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.	6720A ROCKLEDGE DR	BETHESDA	MD	20817	MONTGOMERY	USA	Allergy and Infectious Diseases Research	000	1	5/26/2026	NEW	$223,728
														Subtotal = $223,728

Grand Total All Awards = $223,728

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Efficacy of a whole inactivated vaccine against EV-D68 infection

Award Number: R21AI199351

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/22/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2028

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