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Regulation of infectious spore formation in the fungal pathogen Coccidioides posadasii

Award Number: R21AI193607
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Regulation of infectious spore formation in the fungal pathogen Coccidioides posadasii - SUMMARY The human fungal pathogen Coccidioides causes Valley Fever, a treatment-refractory and sometimes deadly disease prevalent in arid regions of the western hemisphere. Patients contract the disease by inhaling fungal spores from soil. Understanding Coccidioides behavior in the environment is thus key to public health measures for Valley Fever prediction and prevention. We propose a first-ever molecular study of the environmental life cycle of Coccidioides toward this end. Our preliminary work has shown that Coccidioides preferentially makes infectious spores in dry conditions. We now want to know how. We apply experimental- and computational- genomic approaches to dissect desiccation response in Coccidioides outside the host. The rich data sources we generate will pinpoint candidate genes underlying spore formation and will also position us to discover other environmentally-triggered phenotypes in Coccidioides. Our work will open a new wing of the research literature focused on the molecular basis of Coccidioides disease transmission from the environment.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $438,038 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Allergy and Infectious Diseases Research	000	1	7/15/2025	NEW	$438,038
														Subtotal = $438,038

Grand Total All Awards = $438,038

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Regulation of infectious spore formation in the fungal pathogen Coccidioides posadasii

Award Number: R21AI193607

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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