Saturday, October 25, 2025 10/25/2025

Development of a Direct Diagnostic Test for Infectious and Congenital Syphilis

Award Number: R21AI186005
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Development of a Direct Diagnostic Test for Infectious and Congenital Syphilis - PROJECT SUMMARY Current diagnostic tests for syphilis are non-optimal, in that they cannot differentiate active from past infection, cannot diagnose congenital syphilis, and have low sensitivity in early and late disease. With the number of infectious and congenital syphilis cases rapidly expanding in the US and worldwide, curbing the spread of disease will be aided by development of a better diagnostic test that is definitive, easily interpreted, and compatible with a point-of-care test format. In this research application we propose to develop a direct syphilis diagnostic test that: (1) exhibits high sensitivity and specificity at all disease stages; (2) can differentiate active versus past infections; (3) can differentiate syphilis from yaws; (4) can allow accurate disease staging; and (5) can be adapted to a point-of-care format for ease of testing in remote areas.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $91,363 )
2025	2025	UNIVERSITY OF VICTORIA	3800 FINNERTY RD	VICTORIA	BC			CAN	Allergy and Infectious Diseases Research	000	2	9/5/2025	NON-COMPETING CONTINUATION	$75,363
2025	2025	UNIVERSITY OF VICTORIA	3800 FINNERTY RD	VICTORIA	BC			CAN	Allergy and Infectious Diseases Research	001	2	9/15/2025	SUPPLEMENT FOR EXPANSION	$16,000
														Subtotal = $91,363

Issue Date FY: 2024 ( Subtotal = $260,760 )
2024	2024	UNIVERSITY OF VICTORIA	3800 FINNERTY RD	VICTORIA	BC			CAN	Allergy and Infectious Diseases Research	000	1	8/9/2024	NEW	$260,760
														Subtotal = $260,760

Grand Total All Awards = $352,123

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Development of a Direct Diagnostic Test for Infectious and Congenital Syphilis

Award Number: R21AI186005

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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