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Recent thyme emigrants mitigate viral pulmonary pneumonia

Award Number: R21AI185795
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/23/2024
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Recent thyme emigrants mitigate viral pulmonary pneumonia - Abstract. Despite 100 years and countless scientific advances since the devastating flu pandemic of 1918, viral respiratory illnesses remain a great pandemic threat. The current COVID- 19 outbreak has only emphasized our inability to deal with these deadly viruses. A major shortcoming in treatment is the inability to reduce the massive and life-threatening pulmonary inflammation and injury caused by infection. As we work to develop therapeutic approaches, our lab has turned to the one population that is consistently protected from severe viral pneumonias: children. We postulate that by identifying the mechanisms behind this youthful privilege, we can develop novel therapies to reduce the deadly pneumonia that occurs during severe fatal infection. While just as likely to become infected during viral pandemics, children (ages 4-18) do not typically undergo the severe pulmonary inflammation or mortality that can occur in adults. We are able to recapitulate this protection in prepubescent mice (p23-27) during fatal pandemic flu infection. Our preliminary data show that young mice are less susceptible to mortality and do not undergo the severe pneumonia that is common during severe infection. Moreover, we have discovered that prepubescent mice have sustained output of newly produced CD4+ recent thymic emigrants (RTEs) which migrate to the lung during infection. It has been commonly thought that these cells are unimportant during infection as they are phenotypically “immature”, yet our preliminary data show that thymectomy and removal of RTEs prior to infection leads to exuberant pulmonary inflammation and increased mortality. Further, tracheal instillation of CD4+RTEs during infection reduces pulmonary inflammation, suggesting these cells have ant-inflammatory properties. Taken together, these data lead us to our central hypothesis that sustained output of anti-inflammatory CD4+ RTEs reduces influenza induced pulmonary inflammation. The overall objectives of this exploratory R21 application is to, for the first time, demonstrate the importance of CD4 RTEs in an infectious inflammatory setting and to identify how they reduce inflammation. The rationale for this proposed work is that it will allow for the identification of potential cellular and immune therapies that can be used to reduce life threatening inflammation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $191,250 )
2025	2025	THE ADMINISTRATORS OF TULANE EDUCATIONAL FUND	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Allergy and Infectious Diseases Research	000	2	3/20/2025	NON-COMPETING CONTINUATION	$191,250
														Subtotal = $191,250

Issue Date FY: 2024 ( Subtotal = $229,500 )
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Allergy and Infectious Diseases Research	002	1	9/11/2024	NEW	$22,950
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Allergy and Infectious Diseases Research	001	1	7/5/2024	NEW	$0
2024	2024	ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND, THE	6823 SAINT CHARLES AVE	NEW ORLEANS	LA	70118	ORLEANS	USA	Allergy and Infectious Diseases Research	000	1	5/23/2024	NEW	$206,550
														Subtotal = $229,500

Grand Total All Awards = $420,750

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Recent thyme emigrants mitigate viral pulmonary pneumonia

Award Number: R21AI185795

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/23/2024

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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