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Antibody Mediated Immunity Against Brucella

Award Number: R21AI185488
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/25/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Antibody Mediated Immunity Against Brucella - Abstract: No vaccines are currently licensed to prevent human brucellosis and existing vaccines for livestock are not entirely efficacious. In humans and other animals, Brucella can cause a lifelong infection. However, mechanisms underlying the ability of Brucella to subvert adaptive immunity remain unclear. In this proposal we show that vaccine elicited antibodies alter host metabolism to protect the host against Brucella to some degree. Therefore, in Specific Aim #1 of this proposal we will determine how vaccine-elicited IgM and class switched antibodies alter tissue metabolism to restrict Brucella infection. We also found that Brucella encodes virulence factors that mediate evasion of humoral immunity. Therefore, in Specific Aim #2 of this proposal we will identify mechanisms by which Brucella subverts antibody mediated immunity. Collectively, our results will enhance our understanding of how current vaccines protect the host, and how Brucella is able to subvert adaptive immunity, and thus could improve the rational design of highly effective vaccines for Brucella.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $233,055 )
2025	2025	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Allergy and Infectious Diseases Research	001	2	7/15/2025	NON-COMPETING CONTINUATION	$233,055
2025	2024	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Allergy and Infectious Diseases Research	000	1	4/28/2025	NEW	$0
														Subtotal = $233,055

Issue Date FY: 2024 ( Subtotal = $193,930 )
2024	2024	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Allergy and Infectious Diseases Research	000	1	7/25/2024	NEW	$193,930
														Subtotal = $193,930

Grand Total All Awards = $426,985

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Antibody Mediated Immunity Against Brucella

Award Number: R21AI185488

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/25/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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