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Impacts of Borrelia burgdorferi Gac protein on infectivity and regulation of virulence protein expression

Award Number: R21AI182568
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Impacts of Borrelia burgdorferi Gac protein on infectivity and regulation of virulence protein expression - ABSTRACT We recently found that the Gac DNA-binding protein of Borrelia burgdorferi, the Lyme disease bacterium, functions as a transcriptional repressor of the essential ospC gene. RNA-sequencing (RNA-Seq) analyses of a gac mutant revealed that Gac impacts levels of transcripts of several other virulence-associated proteins, including the alternative sigma factors RpoN and RpoS. Prior studies demonstrated that RpoN is required for expression of RpoS, and both are required for mammalian infection. The planned studies will further investigate the functions of Gac in the Lyme disease spirochete, including its impacts on mammalian and tick infection and molecular characterization of Gac's impacts on rpoN expression. Results of these studies will provide important insights on regulatory mechanisms that control virulence of the Lyme disease spirochete and help identify key components for development of improved, specific antibacterials.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $183,637 )
2025	2025	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Allergy and Infectious Diseases Research	000	2	4/25/2025	NON-COMPETING CONTINUATION	$183,637
														Subtotal = $183,637

Issue Date FY: 2024 ( Subtotal = $222,109 )
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Allergy and Infectious Diseases Research	000	1	5/29/2024	NEW	$199,898
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Allergy and Infectious Diseases Research	001	1	6/3/2024	NEW	$22,211
														Subtotal = $222,109

Grand Total All Awards = $405,746

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Impacts of Borrelia burgdorferi Gac protein on infectivity and regulation of virulence protein expression

Award Number: R21AI182568

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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