Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Induction of Protective Immune Responses Against C. neoformans in Immune Compromised Hosts

Award Number: R21AI181668
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/09/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2026

Group Awards By:

View Award Description

Induction of Protective Immune Responses Against C. neoformans in Immune Compromised Hosts - Cryptococcus neoformans infections are a significant cause of morbidity and mortality among AIDS patients. Cryptococcal meningoencephalitis is the most common disseminated fungal disease in AIDS patients and is responsible for 15% of AIDS-related deaths globally. Because host immune responses are so vital to the control of cryptococcosis, the overall objective of our laboratory is to determine the mechanism(s) necessary to elicit protective immunity against C. neoformans infections in immune deficient hosts. To this end, studies in our laboratory employ a C. neoformans strain engineered to express interferon (IFN)-, designated H99, as a model system to define protective immune responses against C. neoformans. Published studies by our lab demonstrated that immunization with H99 induces protective immunity against cryptococcosis in mice altogether deficient in B cells, CD4+ T cells, CD8+ T cells, NK cells and neutrophils. Preliminary results provided herein suggest that conventional DC1 cells (cDC1s) are critical for the development of macrophage anti- microbial activity, optimal T cell responses and the induction of protective immunity against cryptococcosis. Taken together, our results lead us to hypothesize that cDC1s are critical for the elicitation of protective vaccine-mediated immune responses against cryptococcosis in CD4+ T cell deficient hosts. The foundation for our hypothesis is supported by a scientifically rigorous set of published and preliminary results that demonstrate the potential impact of strategies that prime cDC1s to elicit protective immunity against cryptococcosis in immune deficient hosts. To test our hypothesis, we propose to define the mechanism(s) by which IFN- primed cDC1s mediate protective anti-Cryptococcus immune responses in immune compromised hosts.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	TEXAS CHRISTIAN UNIVERSITY	3101 BELLAIRE DRIVE NORTH	FORT WORTH	TX	76129	TARRANT	USA	Allergy and Infectious Diseases Research	000	2	11/7/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $153,580 )
2025	2025	TEXAS CHRISTIAN UNIVERSITY	3101 BELLAIRE DRIVE NORTH	FORT WORTH	TX	76129	TARRANT	USA	Allergy and Infectious Diseases Research	000	2	12/12/2024	NON-COMPETING CONTINUATION	$153,580
														Subtotal = $153,580

Issue Date FY: 2024 ( Subtotal = $182,359 )
2024	2024	TEXAS CHRISTIAN UNIVERSITY	3101 BELLAIRE DRIVE NORTH	FORT WORTH	TX	76129	TARRANT	USA	Allergy and Infectious Diseases Research	001	1	9/11/2024	NEW	$18,236
2024	2024	TEXAS CHRISTIAN UNIVERSITY	3101 BELLAIRE DRIVE NORTH	FORT WORTH	TX	76129	TARRANT	USA	Allergy and Infectious Diseases Research	000	1	2/9/2024	NEW	$164,123
														Subtotal = $182,359

Grand Total All Awards = $335,939

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Induction of Protective Immune Responses Against C. neoformans in Immune Compromised Hosts

Award Number: R21AI181668

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/09/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2026

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer