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Development and Composition of the Basal Complex During Plasmodium Sporogony

Award Number: R21AI181227
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/23/2024
PERIOD OF PERFORMANCE END DATE: 09/30/2026

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Development and Composition of the Basal Complex During Plasmodium Sporogony - Project Summary Malaria parasites quickly amplify their numbers in both the human host and mosquito vector, with a single parasite capable of creating dozens, hundreds, or thousands of daughter parasites. The formation of merozoites (asexual blood stage, liver stage) or sporozoites (mosquito stage) involves the segmentation of these daughter parasites within the bounds of the initial parasite. This segmentation process has best been defined during schizogony in the asexual blood stage, during which the basal complex is assembled to direct the appropriate partitioning of subcellular contents to each daughter cell. Several stable, core members of the basal complex have been defined in both asexual and sexual stage development through complementary experiments, but nothing is known about the composition or functions of the basal complex during the even more complicated segmentation process involved in sporozoite budding. Therefore, in this proposed work, we will investigate the process of sporozoite segmentation that occurs within the Plasmodium yoelii oocyst using ultrastructural expansion microscopy, focused ion beam-scanning electron microscopy (FIB-SEM), and proximity proteomics. This will enable three-dimensional microscopy-based assessments across the process of sporogony that will focus on the involvement of the basal complex. Proximity proteomics approaches will allow a cross-stage and cross-species comparison of the composition of the basal complex, and provide a first view of how it changes over the lengthy process of sporozoite segmentation, which takes up to 10 days in Anopheles mosquitoes. In accomplishing this proposed work, we will advance our understanding of the cell biological processes that underlie sporozoite budding with these complementary microscopy and proteomic approaches. Our focus on the essential basal complex will provide the molecular landscape that is used for effective sporozoite segmentation required to promote parasite transmission.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Allergy and Infectious Diseases Research	000	2	1/23/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2025 ( Subtotal = $204,327 )
2025	2025	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Allergy and Infectious Diseases Research	000	2	3/20/2025	NON-COMPETING CONTINUATION	$204,327
														Subtotal = $204,327

Issue Date FY: 2024 ( Subtotal = $259,646 )
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Allergy and Infectious Diseases Research	001	1	9/11/2024	NEW	$25,965
2024	2024	THE PENNSYLVANIA STATE UNIVERSITY	201 OLD MAIN	UNIVERSITY PARK	PA	16802	CENTRE	USA	Allergy and Infectious Diseases Research	000	1	5/23/2024	NEW	$233,681
														Subtotal = $259,646

Grand Total All Awards = $463,973

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Development and Composition of the Basal Complex During Plasmodium Sporogony

Award Number: R21AI181227

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/23/2024

PERIOD OF PERFORMANCE END DATE: 09/30/2026

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