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Reovirus induction of host inflammatory responses

Award Number: R21AI178222
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2023
PERIOD OF PERFORMANCE END DATE: 05/31/2026

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Reovirus induction of host inflammatory responses - PROJECT SUMMARY Viral myocarditis is a significant cause of morbidity and mortality worldwide, particularly in children and young adults. Despite the clinical importance of viral myocarditis, the mechanisms by which viruses cause myocarditis are poorly understood. The overall objective of experiments described in this application is to define viral and host determinants that contribute to the development of viral myocarditis. Work proposed in this application uses mammalian orthoreovirus (reovirus), which is a longstanding model for studying viral cardiac infections in neonates. We recently identified a potently myocarditic reovirus strain (T1L/T3DM2) that is highly lethal in neonatal mice. Our preliminary data indicate that the virulence of T1L/T3DM2 is markedly diminished in mice lacking key components of pyroptotic cell death pathway. In this application, we will explore how pyroptosis potentiates reovirus myocarditis. Experiments in Specific Aim 1 will define the role of pyroptosis in the heart during reovirus infection. Experiments in Specific Aim 2 will define mechanism by which reovirus induces pyroptosis using a combination in vivo infections in combination with primary cardiomyocytes. This research will have broad general impact by uncovering broad principles that govern immune mechanisms that contribute to viral cardiac disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Allergy and Infectious Diseases Research	000	2	4/3/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $185,375 )
2024	2024	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Allergy and Infectious Diseases Research	000	2	5/15/2024	NON-COMPETING CONTINUATION	$185,375
														Subtotal = $185,375

Issue Date FY: 2023 ( Subtotal = $223,796 )
2023	2023	UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES	4301 W MARKHAM ST	LITTLE ROCK	AR	72205	PULASKI	USA	Allergy and Infectious Diseases Research	000	1	6/1/2023	NEW	$223,796
														Subtotal = $223,796

Grand Total All Awards = $409,171

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Reovirus induction of host inflammatory responses

Award Number: R21AI178222

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2023

PERIOD OF PERFORMANCE END DATE: 05/31/2026

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