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Addressing genetic tractability and species-specific infection biology in Chlamydia pneumoniae

Award Number: R21AI173735
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Addressing genetic tractability and species-specific infection biology in Chlamydia pneumoniae - ABSTRACT Chlamydia species represent a paradigm for understanding successful obligate intracellular parasitism. While C. trachomatis and C. pneumoniae are both prevalent human pathogens, C. pneumoniae respiratory infections are likely most common. Acute C. pneumoniae infections manifest as community acquired pneumonia, bronchitis, and sinusitis while additional inflammatory sequelae are associated with chronic infection. Advances in genetic tractability have facilitated considerable progress in characterizing C. trachomatis pathogenesis. Unfortunately, similar progress has lagged for C. pneumoniae, leading to a paucity in details regarding molecular mechanisms of infection and precluding informative approaches leveraging comparative studies. To overcome this barrier, we will engineer plasmid systems enabling allelic replacement and ectopic gene expression for C. pneumoniae. These new technologies will be applied in proof-of-principle studies to address functional aspects manifested by a pair of divergent type III secreted effectors employed by C. pneumoniae to manipulate host cell biology. At the end of these studies, we will have established new approaches that will benefit the entire Chlamydia research community and advance the understanding of how chlamydial species have evolved to accomplish common developmental requirements.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $191,250 )
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Allergy and Infectious Diseases Research	001	2	5/10/2024	NON-COMPETING CONTINUATION	$19,125
2024	2024	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE	LEXINGTON	KY	40526	FAYETTE	USA	Allergy and Infectious Diseases Research	000	2	10/23/2023	NON-COMPETING CONTINUATION	$172,125
														Subtotal = $191,250

Issue Date FY: 2023 ( Subtotal = $229,500 )
2023	2023	UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION, THE	500 S LIMESTONE 109 KINKEAD HALL	LEXINGTON	KY	40526	FAYETTE	USA	Allergy and Infectious Diseases Research	000	1	11/7/2022	NEW	$229,500
														Subtotal = $229,500

Grand Total All Awards = $420,750

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Addressing genetic tractability and species-specific infection biology in Chlamydia pneumoniae

Award Number: R21AI173735

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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