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Developing mouse models to study circulating memory to Chlamydia infection

Award Number: R21AI169123
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/10/2022
PERIOD OF PERFORMANCE END DATE: 10/31/2025

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Developing mouse models to study circulating memory to Chlamydia infection - Chlamydia infections are a cause of blindness worldwide and a major cause of sexually transmitted disease in the US. Greater understanding of protective immunity to Chlamydia at mucosal surfaces is urgently required if an effective vaccine is to become a reality. This application will examine fundemental aspects of protective CD4 T cells during infection of the female reproductive tract mucosa. Our experimental approach is unique in that it utilizes a natural route of infection, uses an established model where CD4 T cells participate in bacterial clearance, and allows for direct visualization of endogenous and transferred Chlamydia-specific CD4 T cells. Our application specifically proposes to establish new mouse models to understand the mechanism of protection mediated by circulating memory CD4 T cells and, (i) determine whether innate lymphoid cells recruit memory cells to the FRT, (ii) examine the contribution of memory Th17 cells in coordinating bacterial clearance. Developing these infection models and addressing these issues will expand our knowledge of memory responses to Chlamydia and could be vitally important for the generation of a new vaccine for an important human pathogen.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $190,107 )
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	2	10/26/2023	NON-COMPETING CONTINUATION	$171,097
2024	2024	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	001	2	5/13/2024	NON-COMPETING CONTINUATION	$19,010
														Subtotal = $190,107

Issue Date FY: 2023 ( Subtotal = $230,231 )
2023	2023	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR, STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	1	11/10/2022	NEW	$230,231
														Subtotal = $230,231

Grand Total All Awards = $420,338

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Developing mouse models to study circulating memory to Chlamydia infection

Award Number: R21AI169123

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/10/2022

PERIOD OF PERFORMANCE END DATE: 10/31/2025

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