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Cellular mechanisms linking the intestine to inflammation involving non-intestinal organs

Award Number: R21AI168714
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/16/2023
PERIOD OF PERFORMANCE END DATE: 10/31/2025

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Cellular mechanisms linking the intestine to inflammation involving non-intestinal organs - ABSTRACT Mechanisms driving inflammation, and the possibilities for therapeutic intervention, have expanded dramatically since the discovery that the intestine is linked to inflammatory diseases involving non-intestinal organs. The processes and cell types underpinning this inter-organ link are poorly understood, even for diseases which are coincident with intestinal inflammation. One prominent disease with clear links to intestinal inflammation is primary sclerosing cholangitis (PSC), an immune-mediated disease hallmarked by liver fibrosis. There is no therapy that prevents PSC from getting worse, and liver transplant is the only cure—although sometimes, PSC can return even after liver transplant. The driving forces behind PSC-linked liver fibrosis are thought to originate in the intestine and thus, understanding the inflammatory processes that link intestinal inflammation with liver fibrosis would be a breakthrough for this disease. Moreover, these fundamental discoveries would shine new light into processes that link the intestine to inflammation involving non-intestinal organs, an area that holds potential for transformative therapeutics. This project will unlock some of this potential by dissecting cellular mechanisms linking intestinal inflammation with liver fibrosis in a novel mouse model where these diseases occur concomitantly. These studies will offer specific cell types for targeted approaches to treat diseases linked to the intestine, including PSC-linked liver fibrosis, an unstoppable disease that has no cure.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $186,725 )
2025	2025	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Allergy and Infectious Diseases Research	000	2	11/1/2024	NON-COMPETING CONTINUATION	$186,725
														Subtotal = $186,725

Issue Date FY: 2024 ( Subtotal = $231,000 )
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Allergy and Infectious Diseases Research	001	1	9/11/2024	NEW	$23,100
2024	2024	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Allergy and Infectious Diseases Research	000	1	11/16/2023	NEW	$207,900
														Subtotal = $231,000

Grand Total All Awards = $417,725

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Cellular mechanisms linking the intestine to inflammation involving non-intestinal organs

Award Number: R21AI168714

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/16/2023

PERIOD OF PERFORMANCE END DATE: 10/31/2025

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