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Anti-Malarial Drug Leads from Fungi

Award Number: R21AI163960
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/21/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2024

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Anti-Malarial Drug Leads from Fungi - Project Summary There is a need for new antimalarial drug leads, particularly for treating drug resistant malaria. Fungi have been the source of many drug leads, with penicillin and the statins as two of the most prominent examples. We hypothesize that fungi harbor antimalarial drug leads, and we are addressing this via a team with expertise in mycology (Mycosynthetix/Pearce), natural products chemistry (UNCG/Oberlies), and parasitology/malaria (UGA/Kyle). In the examination of 40,000 fungal cultures from the Mycosythetix library, we have implemented biological and chemical protocols to prioritize our efforts. In doing so, we have now selected 8 fungal cultures that have potent antimalarial activity, minimal cytotoxicity to mammalian cells, and do not biosynthesize common nuisance compounds (i.e. mycotoxins). That averages to the analysis of ~1 fungal culture per quarter over this 2 year project. Our team is poised to isolate, elucidate, and evaluate antimalarial drug leads from these cultures. In addition, we will prioritize the 1 to 2 best leads, such that ample materials are produced for more in depth biological evaluation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$429 )
2025	2022	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN ST	GREENSBORO	NC	27412	GUILFORD	USA	Allergy and Infectious Diseases Research	000	2	11/26/2024	NON-COMPETING CONTINUATION	-$429
														Subtotal = -$429

Issue Date FY: 2022 ( Subtotal = $172,897 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN STREET	GREENSBORO	NC	27412	GUILFORD	USA	Allergy and Infectious Diseases Research	000	2	4/18/2022	NON-COMPETING CONTINUATION	$172,897
														Subtotal = $172,897

Issue Date FY: 2021 ( Subtotal = $225,872 )
2021	2021	UNIVERSITY OF NORTH CAROLINA AT GREENSBORO	1000 SPRING GARDEN STREET	GREENSBORO	NC	27412	GUILFORD	USA	Allergy and Infectious Diseases Research	000	1	5/21/2021	NEW	$225,872
														Subtotal = $225,872

Grand Total All Awards = $398,340

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Anti-Malarial Drug Leads from Fungi

Award Number: R21AI163960

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/21/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2024

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