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COVID_Breastfeeding with COVID 19 disease: SARS-CoV-2 antibodies in breast milk and disease progression in the first six months of life

Award Number: R21AI159939
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT It is unknown whether COVID-19 positive mothers transmit SARS-CoV-2 antibodies in their breast milk to protect their newborns or if breastfeeding can pose a risk of infection (either through consumption of virus or direct contact with the mother during feedings). Scientists hypothesize that (1) the breast milk of these mothers may have SARS-CoV-2 neutralizing antibodies which may confer protection; or (2) their breast milk can pose a risk of infection if the virus is shed in breast milk and consumed by the infant. Limited data are available thus far to support either hypothesis. As a result, SARS-CoV-2 related breastfeeding recommendations from the World Health Organization (WHO), Centers for Disease Control and Prevention (CDC) and American Academy of Pediatrics (AAP) differ. However, previous research has shown that consumption of breast milk in early life confers immunity against several infectious diseases. Evidence-based recommendations for any guidelines require research and clinical studies. The goals of this research are to address this gap and determine if breast milk consumption can confer immunity. These goals will be met through the following specific aims. Specific Aim 1. Detect and quantify SARS-CoV-2 IgM/IgG/IgA antibodies that are present in breast milk and saliva from mother/infant dyads over 6 months. Specific Aim 2. Detect the presence of neutralizing antibodies in breast milk and saliva samples from mother/infant dyads. Specific Aim 3. Determine if and how consumption of breast milk from a COVID-19 positive mother affects SARS-CoV-2 infection, progression and possible recurrence in their infants.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $211,460 )
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Allergy and Infectious Diseases Research	000	2	5/27/2022	NON-COMPETING CONTINUATION	$211,460
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Allergy and Infectious Diseases Research	001	2	7/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $211,460

Issue Date FY: 2021 ( Subtotal = $273,071 )
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Allergy and Infectious Diseases Research	000	1	6/18/2021	NEW	$273,071
														Subtotal = $273,071

Grand Total All Awards = $484,531

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COVID_Breastfeeding with COVID 19 disease: SARS-CoV-2 antibodies in breast milk and disease progression in the first six months of life

Award Number: R21AI159939

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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