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Yolk protein-mediated germline delivery in vector snails

Award Number: R21AI153469
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2021
PERIOD OF PERFORMANCE END DATE: 02/29/2024

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Yolk protein-mediated germline delivery in vector snails - SUMMARY Genetics-based vector control holds great promise in combating vector transmitted diseases. Such a promising strategy, however, has not yet been tested in any vector snail control program of schistosomiasis, one of the world’s most devastating parasitic diseases. The key reason is the lack of a germline delivery technology for delivering genetic materials into gametes or embryos. The inability to deliver genetic materials into snail germline cells is due to the complex anatomical structure of its gametes, the exceedingly small size of its eggs, and its unusual reproductive system, which preclude the application of all existing, well-developed genetic delivery technologies. To circumvent these limitations, we propose an innovative approach that exploits snail yolk proteins as vehicles for shuttling genetic materials into growing oocytes via the natural process of receptor- mediated endocytosis during vitellogenesis. Two types of the most promising snail yolk proteins, yolk ferritin and vitellogenin, both found present in the genome of the schistosomiasis vector snail Biomphalaria glabrata, will be investigated. We will first identify a highly efficient oocyte receptor-binding ligand from snail yolk ferritin or vitellogenin (Aim1) and then test the identified ligand in delivering clustered regularly interspaced short palindromic repeats (CRISPR) cargo into the oocytes for germline modification (Aim 2). This study will open an exciting door for all genetic manipulation studies for basic and applied research of schistosomiasis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	UNIVERSITY OF NEW MEXICO	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87131	BERNALILLO	USA	Allergy and Infectious Diseases Research	000	2	8/28/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $189,375 )
2022	2022	UNIVERSITY OF NEW MEXICO, THE	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Allergy and Infectious Diseases Research	000	2	1/24/2022	NON-COMPETING CONTINUATION	$189,375
														Subtotal = $189,375

Issue Date FY: 2021 ( Subtotal = $221,070 )
2021	2021	UNIVERSITY OF NEW MEXICO, THE	1700 LOMAS BLVD NE STE 2200	ALBUQUERQUE	NM	87106	BERNALILLO	USA	Allergy and Infectious Diseases Research	000	1	2/26/2021	NEW	$221,070
														Subtotal = $221,070

Grand Total All Awards = $410,445

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Yolk protein-mediated germline delivery in vector snails

Award Number: R21AI153469

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2021

PERIOD OF PERFORMANCE END DATE: 02/29/2024

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