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Development of the ferret model for EV-D68 infection

Award Number: R21AI152076
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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Development of the ferret model for EV-D68 infection - ABSTRACT Acute Flaccid Myelitis (AFM) is a debilitating condition in young children. The exact cause of AFM is currently unknown though EV-D68, an enterovirus has been temporally associated with AFM. The exact mechanism's by which EV-D68 causes spinal cord and CNS pathology is not known. Here we propose the development of an immunocompetent small animal model, namely the ferret to study EV-D68 infections. Ferrets have been widely used as a model to study respiratory pathogens such as influenza, RSV, SARS, Hendra and Nipah viruses. Given that the lower respiratory tract is the primary route of entry for EV-D68, we hypothesize that ferrets will serve as a viable model to study EV-D68 pathogenesis. In aim 1, we will develop the model of intranasal infection and delineate the correlates of pathogenesis and immunity, and in aim 2 we will develop a novel avian paramyxovirus based EV-D68 vaccine to examine its potential to prevent intranasal challenge. These studies will provide novel insights into the mechanisms of EV-D68 pathogenesis and vaccine mediated protection from respiratory infections.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.	6720A ROCKLEDGE DR	BETHESDA	MD	20817	MONTGOMERY	USA	Allergy and Infectious Diseases Research	000	2	2/5/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.	6720A ROCKLEDGE DR	BETHESDA	MD	20817	MONTGOMERY	USA	Allergy and Infectious Diseases Research	000	2	8/23/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $152,496 )
2021	2021	HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC., THE	6720-A ROCKLEDGE DR STE 100	BETHESDA	MD	20817	MONTGOMERY	USA	Allergy and Infectious Diseases Research	000	2	7/21/2021	NON-COMPETING CONTINUATION	$152,496
														Subtotal = $152,496

Issue Date FY: 2020 ( Subtotal = $266,869 )
2020	2020	HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC., THE	6720-A ROCKLEDGE DR STE 100	BETHESDA	MD	20817	MONTGOMERY	USA	Allergy and Infectious Diseases Research	000	1	9/8/2020	NEW	$266,869
														Subtotal = $266,869

Grand Total All Awards = $419,365

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Development of the ferret model for EV-D68 infection

Award Number: R21AI152076

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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