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Lnc-PINK regulation of innate immunity in lung epithelial cells

Award Number: R21AI152004
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/05/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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Lnc-PINK regulation of innate immunity in lung epithelial cells - PROJECT SUMMARY The influenza virus infects the respiratory tract and may result in acute respiratory distress syndrome and pneumonia associated with a high mortality rate. The long-term goal of this project is to understand the molecular mechanisms how the lung epithelial cells responds to and restricts respiratory virus infection. Innate immunity is the first responder to respiratory pathogen invasion and provides the first line of defense in the lung. Thus enhancing the host defense response against respiratory virus by targeting lung epithelial host factors is a strategy to restrict respiratory virus infection regardless of any viral changes. Long non-coding RNAs (lncRNAs) are mRNA-like transcripts with a size of > 200 nucleotides, but that do not encode proteins and are involved in diverse cellular processes including innate immunity. Through RNA sequencing analysis and molecular cloning, we have identified a novel lncRNA transcript, lnc-PINK1-2:5 in lung epithelial cells that reduces influenza virus infection and up-regulates the expression of thioredoxin interacting protein (TXNIP) that activates NLRP3 inflammasomses. Based on this preliminary data, we hypothesized that lnc-PINK1-2:5 restricts respiratory virus infection by activating NLRP3 inflammasomes via upregulating TXNIP gene expression in lung epithelial cells. Aim I will establish the functional roles of lnc-PINK1-2:5 in influenza virus infection of human lung epithelial cells. Aim II will delineate the molecular mechanisms of lnc-PINK1-2:5- mediated restriction of influenza virus in human lung epithelial cells.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Allergy and Infectious Diseases Research	000	2	7/7/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Allergy and Infectious Diseases Research	000	2	3/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Allergy and Infectious Diseases Research	000	2	4/14/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $187,000 )
2022	2022	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Allergy and Infectious Diseases Research	000	2	2/11/2022	NON-COMPETING CONTINUATION	$187,000
														Subtotal = $187,000

Issue Date FY: 2021 ( Subtotal = $224,400 )
2021	2021	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Allergy and Infectious Diseases Research	000	1	3/5/2021	NEW	$224,400
2021	2021	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Allergy and Infectious Diseases Research	001	1	3/9/2021	NEW	$0
														Subtotal = $224,400

Grand Total All Awards = $411,400

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Lnc-PINK regulation of innate immunity in lung epithelial cells

Award Number: R21AI152004

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/05/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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