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Airborne delivery of microbots for chemical and mechanical attack of pulmonary biofilms

Award Number: R21AI138214
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 11/23/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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Airborne delivery of microbots for chemical and mechanical attack of pulmonary biofilms - Project Summary: In cystic fibrosis (CF), treatment is difficult because chronic lung infections lead to biofilm formation and drug-resistant bacterial strains prevent antibiotics from working effectively. Antibiotic approaches specifically designed to address infections in the lung include inhaled antibiotics; however, resistant strains are a significant challenge. For delivery, such inhaled drugs must be formulated within a specified size range. Too large and they do not remain suspended to reach deep within the lungs. Too small and they remain in the air and are simply exhaled without embedding. Our scientific premise is that individual magnetic particles of this optimal size range can be inhaled into the lungs and subsequently assembled in place in the form of wheel-like assemblies, or µwheels, to travel deep down lung pathways and disrupt mucus layers to enhance drug-induced biofilm removal. As both µwheel assembly and driving forces are provided by an external magnetic field, once the procedure is finished, devices “self- disassemble” into small building blocks removable by the body's natural mechanism for removal of dust and other foreign particles in the mucus lining. Our aims include: Aim 1: Identify applied magnetic field conditions that promote µwheel-enhanced biofilm degradation. We will study model P. aeruginosa and CF patient-derived biofilms, with and without artificial sputum, and attach antibiotics or dispersal agents onto the magnetic particle surface and within tortuous microenvironments. We will also use nanoparticle-decorated µwheels to perforate and penetrate the film and test with antibiotic/dispersal agent in solution. Aim 2: Determine conditions that support airborne delivery and transport of µwheels in 3D environments. We will demonstrate airborne delivery of µwheels and translation within 3D models of patient respiratory systems, with and without artificial sputum.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	TRUSTEES OF THE COLORADO SCHOOL OF MINES	1500 ILLINOIS ST	GOLDEN	CO	80401	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	2	3/25/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	TRUSTEES OF THE COLORADO SCHOOL OF MINES	1500 ILLINOIS ST	GOLDEN	CO	80401	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	2	10/27/2021	NON-COMPETING CONTINUATION	$0
2022	2020	TRUSTEES OF THE COLORADO SCHOOL OF MINES	1500 ILLINOIS ST	GOLDEN	CO	80401	JEFFERSON	USA	Allergy and Infectious Diseases Research	001	2	6/21/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $190,589 )
2020	2020	TRUSTEES OF THE COLORADO SCHOOL OF MINES	1500 ILLINOIS ST	GOLDEN	CO	80401	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	2	11/6/2019	NON-COMPETING CONTINUATION	$190,589
														Subtotal = $190,589

Issue Date FY: 2019 ( Subtotal = $228,150 )
2019	2019	TRUSTEES OF THE COLORADO SCHOOL OF MINES	1500 ILLINOIS ST	GOLDEN	CO	80401	JEFFERSON	USA	Allergy and Infectious Diseases Research	000	1	11/23/2018	NEW	$228,150
														Subtotal = $228,150

Grand Total All Awards = $418,739

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Airborne delivery of microbots for chemical and mechanical attack of pulmonary biofilms

Award Number: R21AI138214

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 11/23/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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