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Pch Super Family Regulators of Gram-Negative Pathogens

Award Number: R21AI115193
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/15/2015
PERIOD OF PERFORMANCE END DATE: 03/31/2018

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Pch Super Family Regulators of Gram-Negative Pathogens - ¿ DESCRIPTION (provided by applicant): PerC homologs have been identified in a number of Gram-negative pathogens of clinical importance, including Salmonella enterica, Shigella sp., Klebsiella pneumonia, Enterobacter cloacae, and multiple E. coli serotypes and pathotypes, constituting a super family of regulatory proteins. PerC of EPEC and the PchABC proteins of EHEC are interchangeable in function, activating expression of their respective type III secretion systems, and they are more related by phylogenetic analysis than the other members of the super family. We ask for support to use biochemical and genetic approaches to elucidate the molecular mechanism of PerC control of transcriptional activity in EPEC. As the molecular mechanism of PerC is unknown, we aim to determine how PerC, a surrogate for the Pch proteins of EHEC and other related bacteria, stimulates transcription on the molecular level. Evidence to date suggests that PerC acts not by binding directly to regulatory DNA, but by some other mechanism. Thus our working hypotheses are that PerC acts either by binding to a regulatory protein, modulating DNA binding or by interacting with regulatory RNA. With an understanding of the mechanism of action of the Pch homologs we envision targeting this regulatory pathway for therapeutic intervention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2016	REED INSTITUTE, THE	3203 S E WOODSTOCK BLVD	PORTLAND	OR	97202	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	2	8/21/2018	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $182,420 )
2016	2016	REED COLLEGE	3203 E. WOODSTOCK BLVD.	PORTLAND	OR	97202	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	2	3/4/2016	NON-COMPETING CONTINUATION	$182,420
														Subtotal = $182,420

Issue Date FY: 2015 ( Subtotal = $180,349 )
2015	2015	REED COLLEGE	3203 E. WOODSTOCK BLVD.	PORTLAND	OR	97202	MULTNOMAH	USA	Allergy and Infectious Diseases Research	000	1	4/3/2015	NEW	$180,349
														Subtotal = $180,349

Grand Total All Awards = $362,769

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Pch Super Family Regulators of Gram-Negative Pathogens

Award Number: R21AI115193

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/15/2015

PERIOD OF PERFORMANCE END DATE: 03/31/2018

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