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GENE EXPRESSION PATTERNS IN EARLY LIFE ALLERGY

Award Number: R21AI078511
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2008
PERIOD OF PERFORMANCE END DATE: 03/31/2010

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GENE EXPRESSION PATTERNS IN EARLY LIFE ALLERGY - DESCRIPTION (provided by applicant): The long term objectives of this project are to identify novel genes associated with the pathogenesis of atopic asthma, which have escaped detection employing current expression profiling techniques. Such genes would be prime candidates for future studies on asthma genetics, and potentially would be new drug candidates. To achieve this objective we propose to utilize a new approach which derives from the concept that individual genes do not function in isolation, but instead as members of integrated coexpression networks. We will utilize methodology which has recently been developed for analysis of genome wide microarray expression profiles, that identifies genes based on their connectivity to coordinately expressed genes, and in doing so assigns them to coexpression networks. Of particular interest are highly interconnected genes which serve as hubs to stabilize networks and/or as links between networks. An archetypal example of such hub genes is NF B which integrates signals from multiple interlinked genes and gene networks. In this project we will focus on identification of genes operative within immune response pathways associated with the induction and expression of the disease atopic asthma. Our specific aims are: (i) to identify and characterize gene expression networks operative in Th-cell responses to aeroallergen amongst sensitized atopics; (ii) to identify network level variations in aeroallergen-driven Th-cell gene expression programs amongst sensitized atopics which are associated with expression of the clinical asthmatic phenotype; (iii) to validate these network level variations (and their constituent putative "asthma candidate genes") in an independent study cohort of atopic asthmatics.Narrative This project seeks to develop a new and improved approach to the identification of disease associated genes relevant to the pathogenesis of atopic asthma. Such genes would be prime candidate drug targets. This disease remains a heavy burden on health care services internationally, and more effective drugs for treatment (and prevention) are urgently needed, and the approach to be followed in the project has the potential to develop methods that would markedly improve drug target identification.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2009 ( Subtotal = $123,612 )
2009	2009	TVW TELETHON INSTITUTE FOR CHILD HEALTH RESEARCH	POST OFFICE BOX 855	PERTH				AUS	Allergy and Infectious Diseases Research	000	2	3/19/2009	NON-COMPETING CONTINUATION	$123,612
														Subtotal = $123,612

Issue Date FY: 2008 ( Subtotal = $173,386 )
2008	2008	TVW TELETHON INSTITUTE FOR CHILD HEALTH RESEARCH	POST OFFICE BOX 855	PERTH				AUS	Allergy and Infectious Diseases Research	000	1	3/19/2008	NEW	$173,386
														Subtotal = $173,386

Grand Total All Awards = $296,998

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GENE EXPRESSION PATTERNS IN EARLY LIFE ALLERGY

Award Number: R21AI078511

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2008

PERIOD OF PERFORMANCE END DATE: 03/31/2010

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