Wednesday, October 15, 2025 10/15/2025

L-Rha and L-Rha Derivatives and Their Effects on Neurodegenerative Alzheimer's Disease

Award Number: R21AG095752
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2025
PERIOD OF PERFORMANCE END DATE: 08/31/2027

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L-Rha and L-Rha Derivatives and Their Effects on Neurodegenerative Alzheimer's Disease - Project Summary A rare sugar, L-rhamnose (L-Rha) and L-Rha-containing molecules demonstrated unique effects on Alzheimer’s disease (AD). Despite its importance in human health, it is still not clear how L-Rha plays a role in activation of the signaling pathways that modulate neurons in neurogenesis and the genetic factors related to amyloid β and tau protein. Most studies on L-Rha have used L-Rha-rich oligosaccharides and polysaccharides that are extracted from plants and bacteria, which make it challenging to identify the effect of L-Rha itself and its derivatives on human health. A research team at the University of Toledo will design and synthesize L-Rha-containing molecules with specific sizes and structures using an innovative and novel microwave-assisted chemistry and investigate their effects on growth and transcriptional factors in neurons that are related to the neurogenesis and development of AD. We hypothesize that specific conjugates (glucose and glucuronic acid) and size (dimer and trimer, and oligomers) of L-Rha have optimum effects on AD. Activation of Nrf2, a master regulator of antioxidant response to reactive oxygen species, by L-Rha will be investigated in detail including effects on the reduction of PKB and GSK for controlling p-tau and amyloid-β involved in Alzheimer disease. The synthesis methods will facilitate the production and separation of L-Rha -containing compounds with high yields and purity. These molecules will help us gain a better understanding of the effects of L-Rha sugar on AD treatment and new drug development.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $387,549 )
2025	2025	UNIVERSITY OF TOLEDO	2801 W BANCROFT ST	TOLEDO	OH	43606	LUCAS	USA	Aging Research	000	1	9/15/2025	NEW	$387,549
														Subtotal = $387,549

Grand Total All Awards = $387,549

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L-Rha and L-Rha Derivatives and Their Effects on Neurodegenerative Alzheimer's Disease

Award Number: R21AG095752

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2025

PERIOD OF PERFORMANCE END DATE: 08/31/2027

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