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Systematic investigation of genetic contributions of sex chromosomes to Alzheimer's disease

Award Number: R21AG091567
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/15/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2026

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Systematic investigation of genetic contributions of sex chromosomes to Alzheimer's disease - PROJECT SUMMARY Sex chromosomes have long been excluded in genetic and genomic research of human diseases, partially due to the technical challenges of analyzing the data from large-scale molecular profiling methods, such as next- generation sequencing (NGS). Yet their contributions are significantly implicated in the sex dimorphism of Alzheimer’s disease (AD). In this project, the team will apply a sex-chromosome-completement aware alignment approach to re-align large amounts of NGS data from large clinical cohorts of AD, for systematically investigating the genetic contributions of sex chromosomes to AD. Variants will be called based on the realignments, and both X and Y chromosomes will be specifically investigated for the variants’ associations with AD phenotypes. The team will also consider the contributions of the homologous X-Y gene pairs to gene expression and perform gene network analysis to evaluate how the expressions affect sex differences in AD. The reprocessed data will be disseminated to the public for broad use to benefit the scientific community. Taken together, the work will lay the foundation for determining the genetic components of sex chromosomes to AD and pave the way for future in-depth study of these genomic features and their implication in sexual dimorphism in AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $425,501 )
2025	2025	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	000	1	12/12/2024	NEW	$425,501
2025	2025	ARIZONA STATE UNIVERSITY	660 S MILL AVENUE STE 204	TEMPE	AZ	85281	MARICOPA	USA	Aging Research	001	1	5/29/2025	NEW	$0
														Subtotal = $425,501

Grand Total All Awards = $425,501

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Systematic investigation of genetic contributions of sex chromosomes to Alzheimer's disease

Award Number: R21AG091567

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/15/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2026

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