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Associations between neighborhood environments across the life course and Alzheimer's disease and related dementia outcomes among Hispanic older adults born in and outside the US

Award Number: R21AG089003
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Associations between neighborhood environments across the life course and Alzheimer's disease and related dementia outcomes among Hispanic older adults born in and outside the US - PROJECT SUMMARY Hispanic older adults are 1.5 times more likely to develop Alzheimer’s disease and related dementias (ADRD) compared to White older adults. Social and built environments (SBE) are social determinants of health linked to late-life cognitive function and ADRD risk. Detrimental neighborhood SBE are unevenly distributed across populations and disproportionately affect minoritized groups including US Hispanic populations. Research is growing on neighborhood SBE and ADRD among Hispanic populations, but few studies have investigated their life course neighborhood SBE and how SBE-ADRD associations differ depending on place of birth. In this study, we will use data on Hispanic participants from the Healthy Brain Initiative (HBI), a longitudinal cohort study of ≥50-year-olds without dementia from the racially/ethnically and socioeconomically diverse South Florida region. This study aims to: (1) characterize life course neighborhood SBE (e.g., access to greenspace, socioeconomic status) and how they differ between individuals born in and outside the US; (2) determine whether associations between life course neighborhood SBE exposures and late-life ADRD outcomes vary depending on place of birth (in or outside US) and percentage of life lived in the US; and (3) conduct semi-structured interviews with ~25 Hispanic older adults to develop a richer understanding of neighborhood environments and associated health behaviors and exposures experienced throughout the life course and how they differ between those born in and outside the US. Primary data collection will include administration of a questionnaire on neighborhood SBE from childhood, young adulthood, midlife and late life and semi-structured interviews of HBI participants. In ArcGIS, residential addresses will be geocoded and linked to satellite imagery and Area Deprivation Index data to characterize participants’ neighborhood socioeconomic status and greenspace access. The questionnaire and GIS data will be merged with cognitive (i.e., Cognivue global cognition score and cognitive domains such as episodic memory) and magnetic resonance imaging data (i.e., hippocampal and white matter hyperintensity volume and total brain volume in AD regions of interest). We hypothesize that life course neighborhood SBE exposures and their associations with ADRD outcomes will vary by place of birth and percentage of life lived in the US, and through the semi-structured interviews, we will develop possible explanations for any observed differences that can be tested in subsequent studies. Our study will contribute significantly to the nascent body of research on the impact of acculturation and neighborhood SBE on ADRD risk among Hispanic populations. Study findings will be used to inform novel instrument development on important neighborhood SBE for immigrant and Hispanic populations and key neighborhood SBE features to measure in future grant funded studies on Hispanic ADRD disparities to ultimately inform community-level interventions for these populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $230,024 )
2025	2025	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	000	2	7/7/2025	NON-COMPETING CONTINUATION	$230,024
														Subtotal = $230,024

Issue Date FY: 2024 ( Subtotal = $205,030 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Aging Research	000	1	7/19/2024	NEW	$205,030
														Subtotal = $205,030

Grand Total All Awards = $435,054

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Associations between neighborhood environments across the life course and Alzheimer's disease and related dementia outcomes among Hispanic older adults born in and outside the US

Award Number: R21AG089003

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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