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Integrating Experimental and Computational Models to Study the Prefrontal Microcircuit Changes During Aging and Alzheimer's Disease

Award Number: R21AG087909
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2024
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Integrating Experimental and Computational Models to Study the Prefrontal Microcircuit Changes During Aging and Alzheimer's Disease - The overarching goal of this proposal is to determine and predict microcircuit changes in the prefrontal cortex (PFC) during healthy aging and disease progression in Alzheimer’s disease (AD), by integrating empirical in vivo calcium imaging recording, computational simulation modeling, and calcium imaging-based neural decoding. Functional magnetic resonance imaging studies have suggested disruptions among different brain regions in AD patients. However, PFC microcircuit changes during normal aging and AD initiation and propagation, and how these changes relate to cognitive dysfunctions in AD are poorly understood. We will take a multidisciplinary approach capitalizing on our team’s expertise in miniscope in vivo calcium imaging, simulation modeling and graph theory-based network analysis, and neural decoding. Real-time calcium imaging from awake behaving animals makes it possible to directly visualize the PFC microcircuit changes during aging and dementia. Simulation modeling helps to tease out the primary degeneration and secondary compensatory effects on a microcircuit. Calcium imaging-based neural decoding is a powerful multivariate approach that integrates empirical and computational microcircuit data to understand normal aging and AD pathogenesis processes. Together, we will perform empirical and computational studies simultaneously to determine the impacts of normal aging and various AD related pathologies on the PFC microcircuit. We believe that our strategies will revolutionize our understanding of aging and AD disease progression, and help developing new effective treatments for AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $211,370 )
2025	2025	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Aging Research	000	2	6/26/2025	NON-COMPETING CONTINUATION	$211,370
														Subtotal = $211,370

Issue Date FY: 2024 ( Subtotal = $174,242 )
2024	2024	UNIVERSITY OF WYOMING	1000 E UNIVERSITY AVE	LARAMIE	WY	82071	ALBANY	USA	Aging Research	000	1	8/27/2024	NEW	$174,242
														Subtotal = $174,242

Grand Total All Awards = $385,612

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Integrating Experimental and Computational Models to Study the Prefrontal Microcircuit Changes During Aging and Alzheimer's Disease

Award Number: R21AG087909

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2024

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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