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Modeling glymphatic system and application for aging

Award Number: R21AG070173
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/01/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2025

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Modeling glymphatic system and application for aging - Project Summary Brain was long considered to be devoid of a conventional lymphatic system. However, recent studies led to the conceptualization of a system responsible for the removal of interstitial solute into the cerebrospinal fluid (CSF), mostly around the veins, named, the glymphatic system. This system provides a pathway of highly organized convective fluid flow that drives clearance of interstitial solute from the brain parenchyma. The glymphatic system plays an important role in neurological diseases. Magnetic resonance imaging (MRI) is a suitable non-invasive tool for studying this system, however, few studies have attempted to model the flow through the glymphatic pathways in order to derive quantitative parameters from MRI data. In this project, we will develop, optimize and validate new imaging technique using MRI to derive quantitative maps representing the dynamics of the vascular and glymphatic system. Then, we will investigate aging effects on vascular and glymphatic systems for waste clearance using the optimized imaging technique and analysis. Aging in brain is associated with arterial stiffening and arterial compliance reduction that may led to dementia and Alzheimer disease. Data generated from this application will provide new insights into the efflux pathways of brain waste clearance and provide adequate materials pursuing a translational investigation of this system. If the aims of the project are achieved, significant improvement in patient management will be attained by quantifying the glymphatic system and efflux pathways contribution to neurodegenerative diseases and functional deficits such as TBI, multiple sclerosis, hemorrhage, and epilepsy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Aging Research	000	2	8/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Aging Research	000	2	4/20/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $228,000 )
2023	2023	HENRY FORD HEALTH SYSTEM	1 FORD PL	DETROIT	MI	48202	WAYNE	USA	Aging Research	000	2	4/4/2023	NON-COMPETING CONTINUATION	$228,000
														Subtotal = $228,000

Issue Date FY: 2022 ( Subtotal = $190,000 )
2022	2022	HENRY FORD HEALTH SYSTEM	1 FORD PLACE	DETROIT	MI	48202	WAYNE	USA	Aging Research	000	1	3/18/2022	NEW	$190,000
														Subtotal = $190,000

Grand Total All Awards = $418,000

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Modeling glymphatic system and application for aging

Award Number: R21AG070173

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/01/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2025

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