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Advancing Assessment of Episodic Disability to Enhance Healthy Aging among Adults with HIV: Developing a Short-Form HIV Disability Questionnaire (HDQ) for use in Clinical Practice

Award Number: R21AG062380
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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ABSTRACT The purpose of the proposed study is to develop and pilot the implementation of a short-form HIV-specific disability questionnaire to promote healthy aging among adults aging with HIV. Specific aims are: 1) To develop and assess the utility of a new short-form HIV-specific disability questionnaire across multiple clinical practice settings with older adults with HIV, and 2) To pilot the implementation of the new short-form HIV-specific disability questionnaire, and assess its measurement properties while collecting foundational data on the presence, severity and episodic nature of disability among adults aging with HIV and multimorbidity in the United States, Canada and Ireland. Standardized patient reported outcomes (PROs) designed to capture the nature and extent of disability and its fluctuation over time are critical to guide the provision of timely and appropriate care for adults aging with HIV. In an earlier phase of work, we developed a 69-item Patient Reported Outcome (PRO), called the HIV Disability Questionnaire (HDQ) and demonstrated its reliability and validity among adults living with HIV in Canada and Ireland. As an increasing number of adults age with HIV and multimorbidity, there is a critical need for a brief yet comprehensive assessment of disability that can be routinely and easily administered across health systems in clinical practice. In Phase 1 of this study, we will use psychometric (Rasch analysis) and clinical approaches to develop a short-form version of the HDQ (SF-HDQ). We will then use a combination of quantitative (questionnaires) and qualitative (interviews) with adults aging with HIV and HIV health providers to assess sensibility (face and content validity), utility, and optimal use of the SF-HDQ in clinical practice across three clinical sites in Denver Colorado, Toronto Canada and Dublin Ireland. In Phase 2, we will conduct a cross-sectional pilot study to examine the implementation and assess the measurement properties of the SF-HDQ with adults aging with HIV across the three health systems. Outcomes will yield the first known short form HIV-specific disability PRO developed through international, academic-community collaboration to assess prevalence and impact of episodic disability. Future universal measurement of disability may contribute to ongoing clinical management, specifically tracking of episodic disability trends and evaluation of interventions to inform allocation of resources to better promote healthy aging with HIV.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO	27 KING'S COLLEGE CIR	TORONTO	ON			CAN	Aging Research	000	2	12/21/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO	27 KING'S COLLEGE CIR	TORONTO	ON			CAN	Aging Research	000	2	5/6/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $171,621 )
2020	2020	GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO	27 KING'S COLLEGE CIR	TORONTO	ON	M5S 1A1		CAN	Aging Research	000	2	4/30/2020	NON-COMPETING CONTINUATION	$171,621
														Subtotal = $171,621

Issue Date FY: 2019 ( Subtotal = $175,324 )
2019	2019	GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO	27 KING'S COLLEGE CIR	TORONTO	ON	M5S 1A1		CAN	Aging Research	001	1	8/29/2019	NEW	$0
2019	2019	GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO	27 KING'S COLLEGE CIR	TORONTO	ON	M5S 1A1		CAN	Aging Research	000	1	8/26/2019	NEW	$175,324
														Subtotal = $175,324

Grand Total All Awards = $346,945

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Advancing Assessment of Episodic Disability to Enhance Healthy Aging among Adults with HIV: Developing a Short-Form HIV Disability Questionnaire (HDQ) for use in Clinical Practice

Award Number: R21AG062380

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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