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Mobile Technology-Based Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults with Mild Cognitive Impairment

Award Number: R21AG061494
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2019
PERIOD OF PERFORMANCE END DATE: 11/30/2021

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Mobile Technology-Based Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults with Mild Cognitive Impairment - Abstract The ability to intervene during the risk phase of dementia is paramount in reducing the conversion to dementia- related illnesses and improving long-term outcomes. There is emerging evidence that simultaneously combining physical activities with cognitive tasks leverages neuroplasticity and results in greater cognitive benefits than either of them alone. The proposed R21 project will translate our highly innovative clinic- based simultaneous aerobic exercise and memory skills training (SIM) program into a mobile-based web application for wider dissemination to improve memory functioning in MCI patients. We will first develop and beta test the mobile SIM (mSIM) program at home in 5 amnestic mild cognitive impairment (aMCI; single-domain, primary memory loss) patients over 12-weeks (2 sessions/week, 70 minutes/session) to test feasibility and refine the mSIM program. Each mSIM session will include 20 minutes of sedentary new memory skills introduction and learning through the internet-enabled tablet application, 5 minute aerobic warm-up on the bike (50% Heart Rate Reserve), 40 minutes of memory skills training and practice using our tablet application while aerobic cycling (65-80% HRR), then a 5 minute cool- down. We will conduct a pilot, 12-week RCT by randomly assigning 30 aMCI patients (ages 65-80) to either the mSIM condition (N=15) or an activity monitoring only (via FitBit) control (CON) group (N=15), to study the effects of the mSIM intervention on memory performance and everyday functioning compared to an observational control group. These findings will be used as pilot data for a well- powered NIA R01 clinical trial grant. Elevations in both endogenous levels of brain derived neurotrophic factor (BDNF) and norepinephrine (NE) have been found in response to exercise interventions and were also related to memory improvements in MCI patients. To explore the underlying neurobiological mechanisms of the novel mSIM intervention we will collect peripheral biomarkers of BDNF and NE at baseline and post-intervention. The proposed research will address the following questions: 1. Is a 12 week (2x/week 70 minute) mSIM home-based, technology-enhanced intervention feasible for older adults with aMCI? 2. Does the mSIM intervention improve memory and everyday functioning? 3. Are there increases in underlying exercise-induced neurobiological mechanisms: peripheral BDNF (collected via blood serum) and norepinephrine levels (collected via saliva)? 4. Are elevations in the biomarkers related to improvements in memory functioning?


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $539 )
2023	2020	SAINT JOHN'S CANCER INSTITUTE	2200 SANTA MONICA BLVD	SANTA MONICA	CA	90404	LOS ANGELES	USA	Aging Research	000	2	11/23/2022	NON-COMPETING CONTINUATION	$539
														Subtotal = $539

Issue Date FY: 2022 ( Subtotal = -$539 )
2022	2020	SAINT JOHN'S CANCER INSTITUTE	2200 SANTA MONICA BLVD	SANTA MONICA	CA	90404	LOS ANGELES	USA	Aging Research	000	2	11/16/2021	NON-COMPETING CONTINUATION	$0
2022	2020	SAINT JOHN'S CANCER INSTITUTE	2200 SANTA MONICA BLVD	SANTA MONICA	CA	90404	LOS ANGELES	USA	Aging Research	001	2	4/12/2022	NON-COMPETING CONTINUATION	-$539
														Subtotal = -$539

Issue Date FY: 2020 ( Subtotal = $205,000 )
2020	2020	JOHN WAYNE CANCER INSTITUTE	2200 SANTA MONICA BLVD	SANTA MONICA	CA	90404	LOS ANGELES	USA	Aging Research	001	2	1/23/2020	NON-COMPETING CONTINUATION	$20,500
2020	2020	JOHN WAYNE CANCER INSTITUTE	2200 SANTA MONICA BLVD	SANTA MONICA	CA	90404	LOS ANGELES	USA	Aging Research	000	2	12/2/2019	NON-COMPETING CONTINUATION	$184,500
														Subtotal = $205,000

Issue Date FY: 2019 ( Subtotal = $246,000 )
2019	2019	JOHN WAYNE CANCER INSTITUTE	2200 SANTA MONICA BLVD	SANTA MONICA	CA	90404	LOS ANGELES	USA	Aging Research	000	1	2/26/2019	NEW	$246,000
2019	2019	JOHN WAYNE CANCER INSTITUTE	2200 SANTA MONICA BLVD	SANTA MONICA	CA	90404	LOS ANGELES	USA	Aging Research	001	1	7/1/2019	NEW	$0
														Subtotal = $246,000

Grand Total All Awards = $451,000

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Mobile Technology-Based Simultaneous Aerobic Exercise and Memory Training Intervention for Older Adults with Mild Cognitive Impairment

Award Number: R21AG061494

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2019

PERIOD OF PERFORMANCE END DATE: 11/30/2021

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