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Association of Trabecular Bone Score (TBS) with Incident Fractures in Older Men

Award Number: R21AG046571
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/01/2014
PERIOD OF PERFORMANCE END DATE: 01/31/2017

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Association of Trabecular Bone Score (TBS) with Incident Fractures in Older Men - DESCRIPTION (provided by applicant): Fractures related to osteoporosis are an important cause of morbidity, and in the case of hip fractures, of mortality in the older male population. Since osteoporosis is asymptomatic until a fracture occurs, successful reduction of the societal burden of fractures in men will require that strategies that can identify the subset of men who are at high risk of suffering a fracture, and who should be treated to reduce that risk. Current prediction models have had only partial success achieving this goal, and models incorporating new aspects of bone biology such as bone microstructure are needed to improve fracture prediction in men. In order to be practically applicable to screening a large subset of the overall population as older men represent, such measures need to inexpensive, practical, and easy to implement in clinical practice. Trabecular Bone Score (TBS), a surrogate measure of trabecular microarchitecture, can be easily measured on spine bone density scans (that are routinely done as part of bone density tests) simultaneously as spine bone density is measured. TBS has been shown to be a predictor of major osteoporotic, hip, and clinical vertebral fractures in women, but how well it predicts fractures in men has never been tested. Predictors of changes of TBS over time also have not been explicated. Since TBS is driven by that component of bone (trabecular) with high metabolic activity, there is the possibility that TBS could be a more sensitive indicator of changes in bone strength than areal BMD of the spine (which is often confounded by degenerative changes and aortic calcification) or of the hip (which is mostly cortical bone). Moreover, preliminary evidence from one trial suggests that TBS significantly improves with treatment with at least one therapeutic agent (denosumab), and there is the possibility that TBS could be a more sensitive indicator of response to pharmacologic fracture prevention therapy than other currently available measures. In this ancillary study to the main Osteoporotic Fractures in Men (MrOS) study, and in response to PA-11-261, we propose to measure TBS on the spine bone density scans obtained on 5,994 participants at the baseline visit and 4,485 men attending the second study visit. Our specific aims are; 1) Test the hypotheses that TBS is independently associated with incident hip, radiographic vertebral, and major osteoporotic fractures (clinically evident fractures of the hip, spine, proximal humerus, or distal radius); 2) Test the hypothesis that the addition of TBS to fracture prediction models in older men improves their discrimination of those who will have a fracture from those who will not; and 3) Determine predictors of changes of TBS score between MrOS visits 1 and 2. Establishing the clinical utility of TBS in fracture risk assessment in men will lay the foundation for application in clinical practice to improve fracture prediction and reduce the societal burden of osteoporotic fractures in men.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$12 )
2021	2015	HEALTHPARTNERS INSTITUTE	8170 33RD AVE S	MINNEAPOLIS	MN	55425	HENNEPIN	USA	Aging Research	001	3	10/3/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$12
2021	2015	HEALTHPARTNERS INSTITUTE	8170 33RD AVE S	MINNEAPOLIS	MN	55425	HENNEPIN	USA	Aging Research	000	3	10/1/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$12
2021	2015	HEALTHPARTNERS INSTITUTE	8170 33RD AVE S	MINNEAPOLIS	MN	55425	HENNEPIN	USA	Aging Research	002	3	10/3/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$12
														Subtotal = -$12

Issue Date FY: 2018 ( Subtotal = $12 )
2018	2015	HEALTHPARTNERS INSTITUTE	3311 E OLD SHAKOPEE RD	BLOOMINGTON	MN	55425	HENNEPIN	USA	Aging Research	000	3	7/13/2018	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$12
														Subtotal = $12

Issue Date FY: 2017 ( Subtotal = -$7,531 )
2017	2015	HEALTHPARTNERS INSTITUTE	3311 E OLD SHAKOPEE RD	BLOOMINGTON	MN	55425	HENNEPIN	USA	Aging Research	000	3	6/8/2017	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$7,531
														Subtotal = -$7,531

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	PARK NICOLLET INSTITUTE	3800 PARK NICOLLET BLVD	ST LOUIS PARK	MN	55416	HENNEPIN	USA	Aging Research	001	2	7/12/2016	NON-COMPETING CONTINUATION	-$192,854
2016	2015	HEALTHPARTNERS RESEARCH FOUNDATION	8100 34TH ST, POB 1309	MINNEAPOLIS	MN	55440	HENNEPIN	USA	Aging Research	000	3	7/12/2016	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$192,854
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $226,519 )
2015	2015	PARK NICOLLET INSTITUTE	3800 PARK NICOLLET BLVD	ST LOUIS PARK	MN	55416	HENNEPIN	USA	Aging Research	000	2	2/17/2015	NON-COMPETING CONTINUATION	$226,519
														Subtotal = $226,519

Issue Date FY: 2014 ( Subtotal = $233,525 )
2014	2014	PARK NICOLLET INSTITUTE	3800 PARK NICOLLET BLVD	ST LOUIS PARK	MN	55416	HENNEPIN	USA	Aging Research	000	1	1/20/2014	NEW	$233,525
														Subtotal = $233,525

Grand Total All Awards = $452,513

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Association of Trabecular Bone Score (TBS) with Incident Fractures in Older Men

Award Number: R21AG046571

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/01/2014

PERIOD OF PERFORMANCE END DATE: 01/31/2017

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