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C5A AGONIST AS A VACCINE ADJUVANT FOR THE AGED

Award Number: R21AG031496
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2007
PERIOD OF PERFORMANCE END DATE: 07/31/2009

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C5A AGONIST AS A VACCINE ADJUVANT FOR THE AGED - DESCRIPTION (provided by applicant): A major cause of death in the elderly is infectious disease, due in great measure to the age related loss of immune vigor. The ability to mount a strong immune response declines greatly with age. This is an important factor in the sub-optimal level of protection provided by vaccine to the elderly. The ultimate goal of this research program is to develop a vaccine adjuvant that is effective in the elderly population, using an agonist of the complement C5a receptor as a novel molecular adjuvant. This C5a agonist preferentially binds to the C5a receptor on antigen presenting cells but not to the C5a receptor on inflammatory polymorphonuclear cells. When directly coupled to antigenic epitopes, this C5a agonist peptide can induce Ag-specific CTLs in addition to humoral responses. It targets antigen directly to dendritic cells and enhances the early activation of T lymphocytes from both young and aged mice. Using a well-established mouse model of aging, the first specific aim will identify the specific receptor(s) bound by the C5a agonist. The second aim will examine the immediate biological consequences of activation via the C5a receptor, and the third aim will examine the in vivo response to a C5a agonist-protein conjugate vaccine.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $1,045 )
2010	2008	SAN DIEGO STATE UNIVERSITY, FOUNDATION	SAN DIEGO STATE UNIVERSITY	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	000	3	3/31/2010	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$3,449
2010	2008	SIDNEY KIMMEL CANCER CENTER	10905 Road To The Cure	San Diego	CA	92121	SAN DIEGO	USA	Aging Research	001	2	3/31/2010	NON-COMPETING CONTINUATION	$4,494
														Subtotal = $1,045

Issue Date FY: 2009 ( Subtotal = -$41,458 )
2009	2008	SIDNEY KIMMEL CANCER CENTER	10905 Road To The Cure	San Diego	CA	92121	SAN DIEGO	USA	Aging Research	000	2	8/20/2009	NON-COMPETING CONTINUATION	-$178,276
2009	2008	SAN DIEGO STATE UNIVERSITY, FOUNDATION	SAN DIEGO STATE UNIVERSITY	SAN DIEGO	CA	92182	SAN DIEGO	USA	Aging Research	001	3	8/20/2009	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$136,818
														Subtotal = -$41,458

Issue Date FY: 2008 ( Subtotal = $202,836 )
2008	2008	SIDNEY KIMMEL CANCER CENTER	10835 ALTMAN ROW	SAN DIEGO	CA	92121	SAN DIEGO	USA	Aging Research	000	2	7/29/2008	NON-COMPETING CONTINUATION	$202,836
														Subtotal = $202,836

Issue Date FY: 2007 ( Subtotal = $248,370 )
2007	2007	SIDNEY KIMMEL CANCER CENTER	10835 ALTMAN ROW	SAN DIEGO	CA	92121	SAN DIEGO	USA	Aging Research	000	1	9/26/2007	NEW	$248,370
														Subtotal = $248,370

Grand Total All Awards = $410,793

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C5A AGONIST AS A VACCINE ADJUVANT FOR THE AGED

Award Number: R21AG031496

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2007

PERIOD OF PERFORMANCE END DATE: 07/31/2009

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