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GPR55 receptor signaling in binge alcohol drinking behavior

Award Number: R21AA028884
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/20/2021
PERIOD OF PERFORMANCE END DATE: 02/28/2025

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GPR55 receptor signaling in binge alcohol drinking behavior - Project Summary Alcohol abuse, particularly binge alcohol (ethanol) drinking, is a major public health concern. Recent studies have revealed a high prevalence of binge drinking in adolescence and young adults. Like most drugs of abuse, ethanol use is usually initiated in adolescence leading to short-term as well as long-term negative health consequences, including increased risk for the development of alcohol use disorder (AUD). Although significant advances have been made in understanding the neurobiology of AUD, the effect of binge drinking on the brain and neuronal mechanisms contributing to the behavioral deficits are not yet clearly understood. Recent studies have suggested that an orphan G-protein-coupled receptor 55 (GPR55) signaling plays an important role in health and diseases. However, the role of GPR55 signaling in binge alcohol drinking is currently unknown. The proposed research is focused on understanding the effects of binge alcohol drinking in both adolescence and young adulthood on brain GPR55 signaling, and assess if the drugs targeted to GPR55 regulate binge ethanol drinking using a C57BL/6J mouse model. This study will provide further insight into neuronal mechanism of binge alcohol drinking, and the findings would assist in the development of effective therapeutic interventions for AUD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	140 OLD ORANGEBURG RD BLDG 35	ORANGEBURG	NY	10962	ROCKLAND	USA	Alcohol Research Programs	000	2	8/15/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $194,631 )
2022	2022	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Alcohol Research Programs	000	2	8/22/2022	NON-COMPETING CONTINUATION	$194,631
														Subtotal = $194,631

Issue Date FY: 2021 ( Subtotal = $235,606 )
2021	2021	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	140 OLD ORANGEBURG RD	ORANGEBURG	NY	10962	ROCKLAND	USA	Alcohol Research Programs	000	1	9/20/2021	NEW	$235,606
														Subtotal = $235,606

Grand Total All Awards = $430,237

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GPR55 receptor signaling in binge alcohol drinking behavior

Award Number: R21AA028884

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/20/2021

PERIOD OF PERFORMANCE END DATE: 02/28/2025

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