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Leveraging social determinants via artificial intelligence and peer coaching to address racial disparities in primary care among people who use opioids

Award Number: R18HS029783
ORGANIZATION: AGENCY FOR HEALTH CARE RESEARCH AND QUALITY
OPDIV: AHRQ
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: KDA (KNOWLEDGE/DEVELOPMENT/APPLICATION)
PERIOD OF PERFORMANCE START DATE: 09/30/2023
PERIOD OF PERFORMANCE END DATE: 09/29/2027

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Leveraging social determinants via artificial intelligence and peer coaching to address racial disparities in primary care among people who use opioids - PROJECT SUMMARY Black and Latinx people who use opioids (PWUO) bear a disproportionate burden of opioid overdose deaths. The economic burden faced by Black and Latinx PWUO has also risen due to costs associated with excess mortality and utilization of high-cost healthcare services. Compared to White PWUO, Black and Latinx PWUO are less likely to be initiated on buprenorphine in emergency department (ED) settings and establish care in primary care for the treatment of opioid use disorder (OUD). Racial disparities among PWUO in primary care are driven by social determinants of health (SDH; e.g., lack of peer support or health insurance) and may be partially addressed by adopting innovative mobile health and peer coaching strategies. With NIH support, we have validated a theory-driven, artificial intelligence (AI)-driven texting tool using natural language processing to facilitate real-time text responses to patient queries combined with automated texts facilitating receipt of buprenorphine in office-based opioid treatment (OBOT) and social services that address social determinants of health (SDH). This open source texting tool offers passive reminders, informational content, and interactive two- way response algorithms without personal staff contact. In addition, we have adapted an efficacious cultural and structural humility training for PRCs that goes beyond SDH to also address stigma reduction, discrimination, health habitus, and patient navigation to enhance uptake of primary care and social services for PWUO. Using a three-arm, comparative effectiveness trial design, our specific aims are to: (1) Assess the efficacy of PRC- supported text-based care/services coordination with PWUO + AI-driven SDH-enhanced text messaging (intervention arm-1) vs. AI-driven SDH-enhanced text messaging only (intervention arm-2) vs. TAU or printed social/medical services referrals (control) to enhance the receipt of buprenorphine in OBOT among ED-enrolled Black / Latinx PWUO (N=252); (2) Evaluate the implementation of the multimodal intervention (arm-1) guided by the RE-AIM and CFIR frameworks using in-depth interviews among 3 stakeholder groups: (1) frontline providers (n=10); (2) administrators (n=10); and (3) a subset of the Black and Latinx PWUO from the multimodal intervention arm-1 (n=30); and (3) Identify the resources and estimate the associated cost of implementing and sustaining the multimodal intervention and incorporate this information into a customizable budget-impact tool and conduct a comprehensive economic evaluation to calculate the relative economic value (e.g., cost-per quality-adjusted life years, cost-per OUD treatment days) of each study arm from the healthcare sector, state- policymaker, and societal perspectives which will also inform implementation framed by RE-AIM. Our team is poised to conduct this study given expertise in novel Cultural & Structural Humility Training designed for peers, in open source AI-driven mobile health innovations, and was instrumental in integrating mHealth and telemedicine solutions for patients initiating buprenorphine in primary care. If successful, a multisite effectiveness-implementation hybrid type 1 trial will follow. .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $488,652 )
2024	2024	FRIENDS RESEARCH INSTITUTE, INC.	1040 PARK AVE	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Research on Healthcare Costs, Quality and Outcomes	003	3	8/23/2024	NON-COMPETING CONTINUATION	$564,435
2024	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research on Healthcare Costs, Quality and Outcomes	000	1	5/10/2024	NEW	-$548,486
2024	2023	FRIENDS RESEARCH INSTITUTE, INC.	1040 PARK AVE	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Research on Healthcare Costs, Quality and Outcomes	001	2	5/10/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$548,486
2024	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research on Healthcare Costs, Quality and Outcomes	002	1	6/14/2024	NEW	-$75,783
														Subtotal = $488,652

Issue Date FY: 2023 ( Subtotal = $624,269 )
2023	2023	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Research on Healthcare Costs, Quality and Outcomes	000	1	9/19/2023	NEW	$624,269
														Subtotal = $624,269

Grand Total All Awards = $1,112,921

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Leveraging social determinants via artificial intelligence and peer coaching to address racial disparities in primary care among people who use opioids

Award Number: R18HS029783

ORGANIZATION: AGENCY FOR HEALTH CARE RESEARCH AND QUALITY

OPDIV: AHRQ

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: KDA (KNOWLEDGE/DEVELOPMENT/APPLICATION)

PERIOD OF PERFORMANCE START DATE: 09/30/2023

PERIOD OF PERFORMANCE END DATE: 09/29/2027

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