Saturday, July 5, 2025 7/5/2025

Vaping has an immunosuppressive effect, rendering the lung more susceptible to microbial infections

Award Number: R16HL178696
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/10/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2028

Group Awards By:

View Award Description

Vaping has an immunosuppressive effect, rendering the lung more susceptible to microbial infections - Project Summary/Abstract Respiratory disease carries a significant worldwide burden of morbidity and mortality. Currently it is well understood that tobacco smoking is a major cause of pulmonary/lung inflammation, which can progress onto pulmonary disease. However, significantly less is known about the effects of e-cigarettes (E-cigs) on the lung. Our study will assess whether vaped e-liquid (the actual product consumed/”vaped” by the E-cig user) exposure renders the lung more susceptible to pulmonary distress/disease using an ex vivo human bronchial epithelial cells (HBEC) model followed by our developed in vivo (C57BL/6J) lung injury model. We will also investigate the immune cell populations involved in any resultant lung injury. Hence, the goals of the current proposal are to model lung cell immune dysfunction using HBEC (Aim 1). To assess immune cell involvement/recruitment and lung pathology post-vape exposure using our in vivo model (Aim 2). We will then determine whether pre-exposure to e-liquid aerosol renders C57BL/6J mice more susceptible to pulmonary distress/disease using Klebsiella pneumoniae as a pathogen challenge model (Aim 3). Completion of the proposed Aims will ultimately shed light on the possible health implications of new and emerging tobacco products (such as E-cigs) and provide mechanistic detail on the possible initiation and progression of lung disease in E-cig users.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $187,500 )
2024	2024	NORTH CAROLINA CENTRAL UNIVERSITY	1801 FAYETTEVILLE ST	DURHAM	NC	27707	DURHAM	USA	Lung Diseases Research	000	1	9/10/2024	NEW	$187,500
														Subtotal = $187,500

Grand Total All Awards = $187,500

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Vaping has an immunosuppressive effect, rendering the lung more susceptible to microbial infections

Award Number: R16HL178696

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/10/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2028

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer