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Determining the role of circadian rhythms in Chlamydia associated tubal infertility

Award Number: R16AI175094
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/24/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Determining the role of circadian rhythms in Chlamydia associated tubal infertility - One of the manifestations of Chlamydial pathogenesis in women is tubal factor infertility (TFI). The molecular mechanism underpinning the pathologic changes that cause TFI is poorly understood. We have reported that the time of day of infection influences chlamydia infectivity and pathogenesis. Results from our lab show that when circadian rhythms were disrupted using a Jet lag model, chlamydia-infected mice had increased infectivity and pathology. Our work has demonstrated that miRNAs and genes associated with circadian rhythms are differentially expressed during chlamydia infection. Our premise in this study hypothesizes that circadian rhythms have a role in controlling/regulating chlamydial pathogenesis, leading to infertility. The central goal of this project is to understand the role of circadian rhythms on chlamydial pathogenesis through these aims (1) Investigate the association of host circadian rhythms with chlamydial pathogenesis. We hypothesize that circadian control of chlamydial pathogenesis is essential in determining disease outcomes. We will determine the role and involvement of clock genes Bmal1, Per2, and Cry1 on chlamydial pathogenesis using commercially available Bmal1KO, Per2KO, and Cry1KO mice. (2) Define the circadian control of pathways involved in chlamydial pathogenesis. We hypothesize that the intrinsic disposition of the genital tract to pathogeneic changes will depend on what genes/proteins are activated or inhibited by clock genes. We will also determine genes that are undergoing cycling at different states of chlamydia infection. We will test this hypothesis using C. muridarum infected WT, Bmal1KO, Per2KO, and Cry1KO mice. This study gives us a basis to predict the level of severity of pathogenesis after chlamydia infection and identify new underlying mechanisms involved in chlamydia pathogenesis. By accomplishing the outcomes of the specific aims, we predict that the knowledge gained will positively impact women's reproductive health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $142,000 )
2025	2025	THE MOREHOUSE SCHOOL OF MEDICINE, INC.	720 WESTVIEW DR SW	ATLANTA	GA	30310	FULTON	USA	Allergy and Infectious Diseases Research	000	3	4/30/2025	NON-COMPETING CONTINUATION	$142,000
														Subtotal = $142,000

Issue Date FY: 2024 ( Subtotal = $142,000 )
2024	2024	THE MOREHOUSE SCHOOL OF MEDICINE, INC.	720 WESTVIEW DR SW	ATLANTA	GA	30310	FULTON	USA	Allergy and Infectious Diseases Research	000	2	4/12/2024	NON-COMPETING CONTINUATION	$142,000
														Subtotal = $142,000

Issue Date FY: 2023 ( Subtotal = $142,000 )
2023	2023	MOREHOUSE SCHOOL OF MEDICINE, INC.	720 WESTVIEW DR SW	ATLANTA	GA	30310	FULTON	USA	Allergy and Infectious Diseases Research	000	1	5/24/2023	NEW	$142,000
														Subtotal = $142,000

Grand Total All Awards = $426,000

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Determining the role of circadian rhythms in Chlamydia associated tubal infertility

Award Number: R16AI175094

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/24/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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