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In vivo relevance of the Schlafen-mediated innate immune mechanism in flavivirus infection

Award Number: R16AI167830
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/22/2023
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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In vivo relevance of the Schlafen-mediated innate immune mechanism in flavivirus infection - ABSTRACT Flaviviruses are important human pathogens including viruses such as West Nile, dengue, and Zika. No specific treatments or vaccines are available against these infections, and no biomarkers exist that allow predicting their outcome, characterized by important clinical variability. Understanding innate antiviral immune responses against flaviviruses, could lead to the identification of disease susceptibility biomarkers and therapeutic targets. We recently demonstrated that the type I interferon-stimulated protein Schlafen 11 (SLFN11) is a novel and potent flavivirus restriction factor. In this application we aim to define, at the molecular level, several aspects of the mechanism of action of SLFN11 and determine the anti-flavivirus activity of other members of the SLFN family, as well as the in vivo relevance of this defense system. Therefore, this investigation is highly relevant and will significantly advance our understanding of the antiviral mechanism of action of SLFN proteins, which is currently unknown.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $154,712 )
2025	2025	THE UNIVERSITY OF TEXAS AT EL PASO	500 W UNIVERSITY AVE	EL PASO	TX	79968	EL PASO	USA	Allergy and Infectious Diseases Research	000	3	6/2/2025	NON-COMPETING CONTINUATION	$154,712
														Subtotal = $154,712

Issue Date FY: 2024 ( Subtotal = $154,648 )
2024	2024	THE UNIVERSITY OF TEXAS AT EL PASO	500 W UNIVERSITY AVE	EL PASO	TX	79968	EL PASO	USA	Allergy and Infectious Diseases Research	000	2	5/1/2024	NON-COMPETING CONTINUATION	$154,648
														Subtotal = $154,648

Issue Date FY: 2023 ( Subtotal = $151,360 )
2023	2023	UNIVERSITY OF TEXAS AT EL PASO	500 W UNIVERSITY AVE	EL PASO	TX	79968	EL PASO	USA	Allergy and Infectious Diseases Research	000	1	5/22/2023	NEW	$151,360
														Subtotal = $151,360

Grand Total All Awards = $460,720

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In vivo relevance of the Schlafen-mediated innate immune mechanism in flavivirus infection

Award Number: R16AI167830

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/22/2023

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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