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REDUCE-HIV: Research to Enhance Deprescribing and Uptake of Clinical Evidence in Older Adults With HIV

Award Number: R16AG105063
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/15/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2030

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REDUCE-HIV: Research to Enhance Deprescribing and Uptake of Clinical Evidence in Older Adults With HIV - Project Summary Older adults living with HIV experience a disproportionate burden of multimorbidity and polypharmacy due to lifelong antiretroviral treatment and the earlier onset of age-related chronic illnesses. Complex medication regimens increase the risks of inappropriate medication use and related adverse outcomes, including drug-drug interactions, falls and fractures, cognitive impairment, poor quality of life, hospitalization, mortality, and healthcare costs. Deprescribing is a structured process that healthcare providers review medications and reduce or stop those that may no longer provide benefit or may cause harm. Although deprescribing has been shown to improve medication safety in older adults in geriatric and primary care settings, it has not been systematically implemented in HIV care settings. Prior research has identified enablers of deprescribing, but it has also consistently highlighted multilevel barriers at the patient, provider, and healthcare system levels. These barriers include clinical complexity, concerns about adverse outcomes, time and resource constraints, and challenges related to shared decision-making among providers and patients. Building on this evidence, we hypothesize that implementing a co- designed, context-specific deprescribing workflow among HIV care providers will improve the feasibility and acceptability of deprescribing for older adults living with HIV. Accordingly, this project aims to develop and pilot a practical deprescribing approach tailored to older adults with HIV using implementation science strategies. This will be tested in the following specific aims: Aim 1, the project will gather input from key stakeholders to identify patient-, provider-, and clinic- level factors that influence deprescribing in HIV care process; Aim 2, the research team will work collaboratively with stakeholders to codesign a context-specific deprescribing implementation package that fit within the existing clinic workflows; Aim 3, the project will test the feasibility and acceptability of implementing this package in a HIV clinic. The expected outcomes include a better understanding of implementation determinants to deprescribing in HIV care for older adults, a co- designed deprescribing implementation package optimized to HIV care, and feasibility and acceptability data to inform future studies. This project seeks to improve medication safety for older adults living with HIV and lay the groundwork for subsequent large studies evaluating the impact of deprescribing on clinical outcomes. In addition, this research will provide students with hands-on experience in implementation science and HIV research related to health disparities.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $166,288 )
2026	2026	TEXAS SOUTHERN UNIVERSITY	3100 CLEBURNE ST	HOUSTON	TX	77004	HARRIS	USA	Aging Research	000	1	9/8/2026	NEW	$166,288
														Subtotal = $166,288

Grand Total All Awards = $166,288

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REDUCE-HIV: Research to Enhance Deprescribing and Uptake of Clinical Evidence in Older Adults With HIV

Award Number: R16AG105063

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/15/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2030

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