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Reward Devaluation, Positive Valence Systems Disturbance, and Impairment

Award Number: R15MH101573
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/24/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2029

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Reward Devaluation, Positive Valence Systems Disturbance, and Impairment - ABSTRACT/PROJECT SUMMARY Objective. The current study will evaluate tasks examining tenets of reward devaluation theory, including the novel Valence Selection Task, and their ability to predict depression, functioning, and each other among a sample of individuals with normal-to-abnormal symptoms of psychopathology. This application is significant and innovative and has great promise of experimental therapeutics translation. Background. Depression is the leading cause of disability for people aged 15 to 44, with high costs to public health. There is thus great need for research on underlying predictors that help better guide treatment interventions. Reward Devaluation Theory outlines experimental indicators of avoidance of positivity that represent disturbances of Positive Valence Systems, which are commonly observed among depressed persons. Reward Devaluation Theory may thus advance how positive valence systems disturbance is conceptualized and help predict treatment response in depression. Significance. Meta-analytic and experimental findings supporting reward devaluation theory indicate that individuals with depression often avoid rewarding stimuli. This is a discriminant finding that is not present in anxious individuals and is not present when examining responses to negative stimuli. Innovation. Reward devaluation theory is thus a highly innovative framework for interpreting an endophenotypic predictor of positive valence systems disturbance indicated by depressive symptoms. Avoidance (i.e., devaluation, not just lack of valuation) of reward is an underinvestigated phenomenon that has been uncovered by the PI. Our research team has also uncovered evidence suggesting that a new ecologically valid test may have us on the precipice of clinical translation after diligent research and scientifically rigorous analyses showing that reward devaluation is a real phenomenon. Specific Aims. The aims of the proposed project are to examine the Valence Selection Task in relation to other behavioral and self-report indexes of reward devaluation and depression to assess internal validity of this externally valid task for clinical translation and to examine all of these candidate variables using network analysis. Approach. Reward devaluation tasks and self-report measures will be evaluated in a sample with normal-to-abnormal depressive symptom profiles. Participants will be assessed weekly for six weeks. Multilevel linear, correlational, and network modeling will be used for data analysis. Expected Results. Tasks that assess reward devaluation will overlap and predict symptoms of depression and impairment. Moreover, the Valence Selection Task will be central to reward devaluation networks. Future Directions. Our ultimate goal is to use reward devaluation to increase individuals’ self-awareness and readiness to engage with potentially threatening positive information as part of an experimental therapeutics approach.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $518,794 )
2026	2026	THE NEW SCHOOL	66 W 12TH ST	NEW YORK	NY	10011	NEW YORK	USA	Mental Health Research Grants	001	5	5/5/2026	COMPETING CONTINUATION	$569,936
2026	2020	THE NEW SCHOOL	66 W 12TH ST	NEW YORK	NY	10011	NEW YORK	USA	Mental Health Research Grants	000	4	10/1/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$51,142
														Subtotal = $518,794

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2020	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	000	3	2/12/2025	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2020	THE NEW SCHOOL	66 W 12TH ST	NEW YORK	NY	10011	NEW YORK	USA	Mental Health Research Grants	000	4	8/5/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2020	THE NEW SCHOOL	66 W 12TH ST	NEW YORK	NY	10011	NEW YORK	USA	Mental Health Research Grants	001	4	8/23/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	NEW SCHOOL, THE	66 W 12TH ST	NEW YORK	NY	10011	NEW YORK	USA	Mental Health Research Grants	000	4	9/8/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = -$99 )
2022	2020	NEW SCHOOL, THE	66 W 12TH ST	NEW YORK	NY	10011	NEW YORK	USA	Mental Health Research Grants	001	4	12/10/2021	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$371,994
2022	2020	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	000	3	12/10/2021	COMPETING CONTINUATION	-$372,093
														Subtotal = -$99

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	001	3	7/3/2021	COMPETING CONTINUATION	$58,364
2021	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	000	2	7/3/2021	COMPETING CONTINUATION	-$58,364
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $423,178 )
2020	2020	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	000	3	9/11/2020	COMPETING CONTINUATION	$423,178
														Subtotal = $423,178

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	001	2	12/5/2017	COMPETING CONTINUATION	$27,707
2018	2014	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	000	1	12/5/2017	NEW	-$27,707
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $417,379 )
2017	2017	MISSISSIPPI STATE UNIVERSITY	245 BARR AVE MCARTHUR HALL	MISSISSIPPI STATE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	000	2	8/2/2017	COMPETING CONTINUATION	$417,379
														Subtotal = $417,379

Issue Date FY: 2014 ( Subtotal = $416,388 )
2014	2014	MISSISSIPPI STATE UNIVERSITY	P.O. BOX 5227	STATE COLLEGE	MS	39762	OKTIBBEHA	USA	Mental Health Research Grants	000	1	9/24/2014	NEW	$416,388
														Subtotal = $416,388

Grand Total All Awards = $1,775,640

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Reward Devaluation, Positive Valence Systems Disturbance, and Impairment

Award Number: R15MH101573

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/24/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2029

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