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Interactive roles of cardiorespiratory fitness and adiposity on recovery of impaired glucose and vascular control after physical inactivity

Award Number: R15HL177798
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Interactive roles of cardiorespiratory fitness and adiposity on recovery of impaired glucose and vascular control after physical inactivity - Project Summary The far-reaching negative health effects of the reduced physical activity (RPA) epidemic are often overlooked by the general population and health professionals. Short-term RPA induces cardiometabolic dysfunction, including impaired glucose control and vascular function, that may precede disease development. The impact of existing health status on RPA-induced cardiometabolic dysfunction and recovery of impaired glucose control following RPA is unexplored. Thus, our objectives are 1) to investigate the effect of existing health status (cardiorespiratory fitness and adiposity) on the recovery of impaired glucose control following a period of RPA and 2) to determine the role of vascular function as a mechanism of impaired glucose control. Our final objective is to 3) expose undergraduate students to meritorious biomedical clinical research methods. We have piloted the clinical research methods and analysis with undergraduate researcher associates and are well-prepared to complete this proposal. Our preliminary data show that low cardiorespiratory fitness and/or high adiposity impair the recovery of glucose control following short-term RPA. Thus, we aim to examine the interactive role of health status (cardiorespiratory fitness and adiposity) on the ability to recover impaired glucose control following short-term RPA. We also seek to examine changes in vascular function as a mechanism of recovery of impaired glucose control following a return to normal PA. We will recruit men and women with divergent health status (cardiorespiratory fitness and adiposity) to examine glucose control and vascular function during 7-d of normal PA, 7-d of RPA, and 7-d of resumption of normal RA. Continuous glucose monitoring and oral glucose tolerance tests will be performed to assess glucose control. Increases in vascular shear stress induced by passive leg movement and central arterial stiffness will be measured to assess vascular function.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $422,894 )
2025	2025	MIAMI UNIVERSITY	501 E HIGH ST	OXFORD	OH	45056	BUTLER	USA	Cardiovascular Diseases Research	000	1	4/18/2025	NEW	$422,894
														Subtotal = $422,894

Grand Total All Awards = $422,894

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Interactive roles of cardiorespiratory fitness and adiposity on recovery of impaired glucose and vascular control after physical inactivity

Award Number: R15HL177798

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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