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Goodnight mouse: sleep and sepsis

Award Number: R15HL159554
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/06/2022
PERIOD OF PERFORMANCE END DATE: 03/31/2026

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Goodnight mouse: sleep and sepsis - Abstract: Sleep plays a vital role in mammalian physiology. Adequate sleep promotes a healthy immune response, which helps the body fight infections. In the hospital setting, patient sleep is often interrupted due to nighttime nursing care, noise, and artificial light. Sepsis is the leading cause of death in US hospitals. This condition develops when an infection induces a dysregulated immune response, culminating in organ dysfunction. Despite modern medical treatments, the mortality rate for severe sepsis remains very high (30-50%). Prior reports suggest that sleep interruption exacerbates sepsis in mice, increasing animal mortality. However, the mechanisms behind these effects have not been elucidated. This proposal will confirm that sleep interruption exacerbates sepsis in mice, and determine the mechanism of this effect. The knowledge gained will create a foundation for future studies that investigate the intersection between sepsis and sleep in humans. Ultimately, septic patients may benefit from interventions to improve their sleep quantity and quality, or pharmacological interventions to reverse the effects of poor sleep. Additionally, this proposal will provide training opportunities for students enrolled in the Medical School, Masters in Biomedical Science and upcoming PhD in Biomedical Science programs at Mercer University. The graduate student population of Mercer is 64.5% female, 24.5% Black, and 5% Hispanic. The student population also contains a high proportion of people from rural, underserved areas and a significant number of first-generation college graduates. By participating in this project, our students will gain critical research experience, acquiring skills for in vivo and in vitro research techniques, data analysis and statistical analysis, and will gain the opportunity to present their research at a national conference. These activities will greatly enhance their career opportunities and strengthen the infrastructure of research at Mercer University.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	THE CORPORATION OF MERCER UNIVERSITY	1501 MERCER UNIVERSITY DR	MACON	GA	31207	BIBB	USA	Cardiovascular Diseases Research	002	2	3/26/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$1
2025	2022	TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO	130 RICK FRANCIS ST	EL PASO	TX	79905	EL PASO	USA	National Center on Sleep Disorders Research	001	1	3/26/2025	NEW	-$1
2025	2022	THE CORPORATION OF MERCER UNIVERSITY	1501 MERCER UNIVERSITY DR	MACON	GA	31207	BIBB	USA	Cardiovascular Diseases Research	000	2	3/26/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	THE CORPORATION OF MERCER UNIVERSITY	1501 MERCER UNIVERSITY DR	MACON	GA	31207	BIBB	USA	Cardiovascular Diseases Research	001	2	4/4/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$354,464
2024	2022	TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO	5001 EL PASO DR	EL PASO	TX	79905	EL PASO	USA	National Center on Sleep Disorders Research	000	1	4/4/2024	NEW	-$354,464
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $489,160 )
2022	2022	TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO	5001 EL PASO DR	EL PASO	TX	79905	EL PASO	USA	National Center on Sleep Disorders Research	000	1	4/5/2022	NEW	$489,160
														Subtotal = $489,160

Grand Total All Awards = $489,160

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Goodnight mouse: sleep and sepsis

Award Number: R15HL159554

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/06/2022

PERIOD OF PERFORMANCE END DATE: 03/31/2026

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