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Neural Mechanism of Sympathetic Activation in Heart Failure

Award Number: R15HL145655
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2023

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Neural Mechanism of Sympathetic Activation in Heart Failure - SUMMARY: Our long-term goal is to identify the neuronal mechanisms of elevated sympathetic outflow in chronic heart failure (CHF) and provide new targets for treatments of CHF. The objective here is to determine the molecular mechanisms of down-regulation of SK channel function among autonomic PVN neurons and the contribution to sympathetic activation in CHF. Our central hypothesis is that upregulation of microRNA-9-3p is involved in the diminished SK current and expression in autonomic PVN neurons, which contributes to the sympathetic activation in CHF. The rationale for the proposed research is that once the mechanism is known of how 1) SK current is reduced among PVN neurons and 2) diminished SK current contributes to the sympathetic activation in CHF, the data will contribute to new and innovative approaches to the prevention and treatment of CHF. We will test our central hypothesis and accomplish the overall objective by pursuing the following specific aims: 1. To determine the role of miR-9-3p among autonomic PVN neurons in regulating SK current, expression, excitability and sympathetic activation in CHF in vivo. Our working hypothesis is that overexpression of miR-9-3p diminish SK current and expression, thus contributing to increased excitability of autonomic PVN neurons and sympathoexcitation in CHF. 2. To determine the role of miR-9-3p in mediating post-transcriptional inhibition to SK channels expression, SK currents and excitability NG108 and primary culture brain neuron cells in vitro. Our working hypothesis is that upregulation of miR-9-3p is involved in the down-regulation of SK channel expression in the neuron in vitro. 3. To establish an integrated research and educational program in integrative physiology. My training in neuro- and cardiovascular-physiology as well as research expertise that includes electrophysiological techniques and integrative physiology approaches have provided me unique skills to establish distinguished and discovery-based learning environments for both undergraduate and graduate levels.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$380 )
2024	2019	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Cardiovascular Diseases Research	000	1	3/8/2024	NEW	-$380
														Subtotal = -$380

Issue Date FY: 2019 ( Subtotal = $459,000 )
2019	2019	MICHIGAN TECHNOLOGICAL UNIVERSITY	1400 TOWNSEND DR	HOUGHTON	MI	49931	HOUGHTON	USA	Cardiovascular Diseases Research	000	1	7/26/2019	NEW	$459,000
														Subtotal = $459,000

Grand Total All Awards = $458,620

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Neural Mechanism of Sympathetic Activation in Heart Failure

Award Number: R15HL145655

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2023

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