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Examining the effects of exercise on vascular function in obstructive sleep apnea

Award Number: R15HL133884
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/25/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2021

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Examining the effects of exercise on vascular function in obstructive sleep apnea - Abstract: Obstructive sleep apnea (OSA) is a serious medical condition that affects an estimated 15 million US adults and is characterized by repeated episodes of upper airway obstruction, recurrent arousals and episodic oxyhemoglobin desaturations during sleep. These abnormalities contribute to subclinical alterations in vascular function that increase the risk of cardiovascular disease morbidity and mortality. In contrast, exercise decreases the risk of cardiovascular events and the promotion of physical activity continues to be at the top of our national public health agenda, as seen in the publication of the 1996 report of the US Surgeon General on physical activity and health. While the exact mechanisms for this protective benefit are not entirely clear, there is good evidence that exercise confers cardioprotection through its direct impact on vascular endothelial function. The American College of Sleep Medicine recommends exercise as a behavioral treatment option for OSA. Yet, most clinical trials upon which this recommendation is based have focused on establishing the effectiveness of lifestyle change (e.g., dietary induced weight loss and increased physical activity participation) for improving OSA severity in obese individuals, whereas less attention has been given to whether OSA moderates the effects of exercise on the cardiovascular disease substrate. Our overarching hypothesis is that OSA attenuates the beneficial effect of exercise on vascular function in obese individuals suffering from untreated OSA. The aims of the study are to 1) examine parameters of vascular function in obese persons with and without OSA, 2) evaluate the effects of an acute bout of exercise on brachial artery flow mediated dilation in obese persons with and without OSA, and 3) examine the effects of 6 weeks of exercise training on vascular function among those with and without OSA. Our data will be immediately useful in clinical practice and inform how we prescribe exercise and implement lifestyle changes to reduce cardiovascular disease risk in OSA patients.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$1 )
2022	2016	TOWSON UNIVERSITY	8000 YORK RD	BALTIMORE	MD	21252	BALTIMORE	USA	Cardiovascular Diseases Research	001	1	12/15/2021	NEW	$0
2022	2016	TOWSON UNIVERSITY	8000 YORK RD	BALTIMORE	MD	21252	BALTIMORE	USA	Cardiovascular Diseases Research	000	1	10/1/2021	NEW	-$1
														Subtotal = -$1

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2016	TOWSON UNIVERSITY	8000 YORK RD	BALTIMORE	MD	21252	BALTIMORE	USA	Cardiovascular Diseases Research	000	1	4/7/2021	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2016	TOWSON UNIVERSITY	8000 YORK RD	BALTIMORE	MD	21252	BALTIMORE	USA	Cardiovascular Diseases Research	000	1	6/18/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2016	TOWSON UNIVERSITY	8000 YORK RD	BALTIMORE	MD	21252	BALTIMORE	USA	Cardiovascular Diseases Research	000	1	6/10/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2016	TOWSON UNIVERSITY	8000 YORK RD	BALTIMORE	MD	21252	BALTIMORE	USA	Cardiovascular Diseases Research	000	1	6/20/2017	NEW	-$441,528
2017	2016	TOWSON UNIVERSITY	8000 YORK RD	BALTIMORE	MD	21252	BALTIMORE	USA	Cardiovascular Diseases Research	001	1	6/24/2017	NEW	$441,528
														Subtotal = $0

Issue Date FY: 2016 ( Subtotal = $441,528 )
2016	2016	MD ST OFFICE OF THE GOVERNOR	301 WEST PRESTON ST 15TH FL	BALTIMORE	MD	21201	BALTIMORE CITY	USA	Cardiovascular Diseases Research	000	1	7/22/2016	NEW	$441,528
														Subtotal = $441,528

Grand Total All Awards = $441,527

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Examining the effects of exercise on vascular function in obstructive sleep apnea

Award Number: R15HL133884

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/25/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2021

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