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Adaptive evolutionary inference frameworks for understudied populations using generative neural networks

Award Number: R15HG011528
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 12/18/2020
PERIOD OF PERFORMANCE END DATE: 06/06/2024

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Adaptive evolutionary inference frameworks for understudied populations using generative neural networks - PROJECT SUMMARY In the field of population genetics, machine learning methods are emerging as promising frameworks for understanding evolution. However, these algorithms rely heavily on simulated datasets, which currently fail to recapitulate the features of diverse natural genomes. Deep neural networks in particular are disconnected from evolutionary modeling, and their results are difficult to interpret in a biological context. In this project, we propose to develop simulation frameworks that automatically adapt to any population or species. The resulting customized synthetic datasets will be used to train neural networks that quantify the unique evolutionary histories of understudied human groups. By including genealogical and epigenetic information as auxiliary input, we will be able to link predictions back to genomic features. Our results will enable us to estimate the interactions between local phenomena such as natural selection, mutation patterns, and recombination hotspots. Taken together, outcomes from our work will allow us to create a detailed model evolutionary of processes, both along the genome and across human populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2021	THE CORPORATION OF HAVERFORD COLLEGE	370 W LANCASTER AVE	HAVERFORD	PA	19041	MONTGOMERY	USA	Human Genome Research	000	1	3/4/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $350,141 )
2024	2024	THE CORPORATION OF HAVERFORD COLLEGE	370 W LANCASTER AVE	HAVERFORD	PA	19041	MONTGOMERY	USA	Human Genome Research	002	2	6/6/2024	COMPETING CONTINUATION	$350,141
2024	2021	THE CORPORATION OF HAVERFORD COLLEGE	370 W LANCASTER AVE	HAVERFORD	PA	19041	MONTGOMERY	USA	Human Genome Research	000	1	12/12/2023	NEW	$0
2024	2021	THE CORPORATION OF HAVERFORD COLLEGE	370 W LANCASTER AVE	HAVERFORD	PA	19041	MONTGOMERY	USA	Human Genome Research	001	1	5/31/2024	NEW	$0
														Subtotal = $350,141

Issue Date FY: 2021 ( Subtotal = $432,494 )
2021	2021	CORPORATION OF HAVERFORD COLLEGE, THE	370 LANCASTER AVE	HAVERFORD	PA	19041	MONTGOMERY	USA	Human Genome Research	000	1	12/18/2020	NEW	$389,243
2021	2021	CORPORATION OF HAVERFORD COLLEGE, THE	370 LANCASTER AVE	HAVERFORD	PA	19041	MONTGOMERY	USA	Human Genome Research	001	1	2/9/2021	NEW	$43,251
														Subtotal = $432,494

Grand Total All Awards = $782,635

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Adaptive evolutionary inference frameworks for understudied populations using generative neural networks

Award Number: R15HG011528

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 12/18/2020

PERIOD OF PERFORMANCE END DATE: 06/06/2024

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