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Mechanics of overground, dry, and aquatic treadmill walking in children & adolescents with cerebral palsy

Award Number: R15HD109666
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Mechanics of overground, dry, and aquatic treadmill walking in children & adolescents with cerebral palsy - Abstract This project will determine biomechanical mechanisms to optimize walking rehabilitation in overground, dry treadmill, and wet treadmill environments for children with cerebral palsy (CP). Cerebral palsy is a neurological disorder caused by brain damage in early development that impairs motor control and overall mobility. Common gait issues in children with CP are excessive knee flexion, excessive hip flexion/adduction, and high muscular demand. Additionally, children with CP have lower-limb muscle weakness and low joint ranges of motion (ROM). These are speculated as key mechanisms decreasing walking endurance, independence, and quality of life. Less understood is how lower limb kinematics and muscle activity are modified amongst different walking environments commonly used in rehabilitation. In addition, post-operative tolerance to various walking speeds has not been rigorously examined in children with CP. Through descriptive studies, we will perturb walking speed amongst diverse walking environments, characterize within-subject changes to spatiotemporal walking parameters, and establish a fulsome evidence base to design future clinical trials. We hypothesize that walking environment will impact lower limb kinematics and muscle activity due to hydrodynamic drag and altered walking strategies. Furthermore, we hypothesize that the impact of walking environment will vary base on speed. Aim 1: Determine the effects of walking speed and environment on lower body kinematics and muscular demand in children with CP. Aim 2: Link overground walking function with lower body kinematics and muscular demand in diverse walking rehabilitation conditions. Aim 3: Establish post-operative functional differences for walking rehabilitation in children with CP that receive Distal Femoral Extension Osteotomy (DFEO) or Anterior Distal Femoral Hemiepiphysiodesis (ADFH). Considering the ubiquity of post-operative rehabilitation, the clinical importance of data-driven interventions for children with CP is difficult to overstate.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$319 )
2026	2022	UNIVERSITY OF NEBRASKA	6001 DODGE ST EAB 209	OMAHA	NE	68182	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	1	3/3/2026	NEW	-$319
														Subtotal = -$319

Issue Date FY: 2022 ( Subtotal = $448,118 )
2022	2022	UNIVERSITY OF NEBRASKA	6001 DODGE ST EAB 209	OMAHA	NE	68182	DOUGLAS	USA	Child Health and Human Development Extramural Research	000	1	8/30/2022	NEW	$448,118
														Subtotal = $448,118

Grand Total All Awards = $447,799

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Mechanics of overground, dry, and aquatic treadmill walking in children & adolescents with cerebral palsy

Award Number: R15HD109666

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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